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• W80852794 abstract "Recent studies have finally substantiated the long-held hypothesis that c-Myc binds to specific DNA sequences. Myc binds the palindromic consensus sequence CANNTG that is recognized by all basic regions of members of the bHLHZip family.1 Studies using pools of random oligonucleotides, the polymerase chain reaction, and recombinant fusion Myc protein along with electrophoretic mobility gel shift assay indicate that the preferred core binding site for Myc is CACGTG.1 Full length c-Myc is unable to bind DNA by itself, unless a significant portion of its N-terminal is removed.2 Although truncated c-Myc binds the consensus sequence as a homodimer in vitro only when present at very high protein concentrations, full-length c-Myc binds DNA more efficiently as a heterodimer with its partner protein Max.1–3 The core sequence CACATG was also bound by Myc-Myc, Myc-Max, and Max-Max to similar extent.2,4–8 Additional studies indicate that the binding of Myc to this core hexanucleotide shows preference for specific flanking nucleotides as well: GAC(cacgtg)GTC.9,10 The flanking sequences may be important in Myc DNA binding as another bHLHZip protein, USF, recognizes the same canonical sequence, but prefers alternative flanking nucleotides.11,12" @default.
• W80852794 created "2016-06-24" @default.
• W80852794 creator A5031598036 @default.
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• W80852794 date "1995-01-01" @default.
• W80852794 modified "2023-09-28" @default.
• W80852794 title "DNA Binding Properties of Myc" @default.
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• W80852794 doi "https://doi.org/10.1007/978-3-662-22681-0_9" @default.
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