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• W808542018 abstract "Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis." @default.
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• W808542018 date "2015-06-26" @default.
• W808542018 modified "2023-09-28" @default.
• W808542018 title "New Metrics for Evaluating Viral Respiratory Pathogenesis" @default.
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• W808542018 doi "https://doi.org/10.1371/journal.pone.0131451" @default.
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