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- W810233249 abstract "THE ROLE OF CANNABINOIDS AND CANNABINOID RECEPTORS IN ENTERIC NEURONAL SURVIVAL By Yan Li A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University 2009 Major Director: John R. Grider, Professor, Department of Physiology and Biophysics The Endocannabinoid system has been found in the gastrointestinal tract, where it plays an important role in gut under both physiological and pathological conditions. Although the major effects of cannabinoids in the gut are mediated through effects on enteric neurons, the role of cannabinoids in the enteric nervous system is poorly understood. In the present study, we have used the primary cultures of myenteric ganglia and a newly developed fetal enteric neuronal cell line to identify whether the endocannabinoid, anandamide, affects ganglionic and neuronal survival and the pathways involved. Anandamide had a biphasic effect on ganglionic survival, increasing survival at low concentrations (1nM-0.1uM) and decreasing survival at high concentrations (1-10uM). Maximal survival (68% increase in number of ganglia surviving) occurred at 0.1uM and the ED50 was 3nM. This effect on promoting survival was inhibited by the CB1 antagonist AM251 (1uM) and by AraC (10uM), but not the CB2 antagonist AM630" @default.
- W810233249 created "2016-06-24" @default.
- W810233249 creator A5038805449 @default.
- W810233249 date "2009-01-01" @default.
- W810233249 modified "2023-09-23" @default.
- W810233249 title "THE ROLE OF CANNABINOIDS AND CANNABINOID RECEPTORS IN ENTERIC NEURONAL SURVIVAL" @default.
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