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- W810373201 abstract "A number of studies have demonstrated directed migration of neural progenitor cells to sites ofbrain injury and disease. However, a detailed examination of when a cell is ???born??? in relation toinjury induction and the migratory response of that cell has not previously been determined. Thisstudy therefore examined the temporal correlation between progenitor cell proliferation (???birth???)and neuroblast migratory response into the damaged striatum following quinolinic acid (QA)lesioning of the adult rat striatum. Retroviral labeling of subventricular zone (SVZ)???derivedprogenitor cells demonstrated that cell loss in the QA-lesioned striatum increased progenitor cellmigration through the rostral migratory stream for up to 30 days. In addition, a population ofdividing cells originating from the SVZ generated doublecortin positive neuroblasts that migratedinto the damaged striatum in response to cell loss invoked by the QA lesion. The majority ofdoublecortin positive neuroblasts present in the damaged striatum were generated fromprogenitor cells dividing within two days prior to, or on the day of QA lesioning. In contrast, cellsdividing two or more days following QA lesioning, migrated into the striatum and exhibited a glialphenotype. These results demonstrate that directed migration of SVZ-derived cells andneuroblast differentiation in response to QA lesioning of the striatum is acute and transient. Wesubsequently demonstrated a role for the chemokines MCP-1, MIP-1?? and GRO-?? in directingadult SVZ-derived progenitor cell migration following striatal cell death. MCP-1, MIP-1?? andGRO-?? were significantly upregulated in the striatum 2-3 days following QA-induced lesioning,correlating with maximum SVZ-derived progenitor cell recruitment into the lesioned striatum. Weestablished that SVZ-derived progenitor cells express receptors for each chemokine, anddemonstrated MCP-1, MIP-1?? and GRO-?? to be potent chemoattractants for SVZ-derivedprogenitor cells in vitro. Immunofluorescence revealed MCP-1, MIP-1?? and GRO-?? arepredominantly expressed in the striatum by NG2-positive cells that appear to infiltrate from thebloodstream 6 hours following QA lesioning. These results indicate that upregulation of MCP-1,MIP-1??, GRO-?? following striatal cell death leads to chemoattraction of SVZ-derived progenitorcells into the damaged striatum and raises a potential role for blood-derived cells in directing therecruitment of SVZ progenitor cells following brain injury." @default.
- W810373201 created "2016-06-24" @default.
- W810373201 creator A5008522203 @default.
- W810373201 date "2009-01-01" @default.
- W810373201 modified "2023-09-24" @default.
- W810373201 title "The potential role of chemokines in redirecting progenitor cell migration into the lesioned striatum" @default.
- W810373201 hasPublicationYear "2009" @default.
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