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- W81055650 abstract "Increased host lethality was found when a second injection of HU was given at a 20 instead of a 24 hour interval. In this case the ability to predict an improved schedule is predicated on knowing when the tissue has recovered and thus can tolerate another insult. This is in contrast to an earlier injection wherein the tissue would be insulted in the midst of an acute cellular recovery process. We know of no satisfactory data which would justify establishing a clinical trial based only on the synchronization phenomena. New agents and/or techniques need to be developed before in vivo synchronization can be reasonably explored in a clinical context. In the meantime, much more laboratory data are needed on the recovery kinetics of normal and malignant tissues following insults with currently effective therapeutic agents. There is no doubt that correct scheduling based on the recovery kinetics of normal tissues can make available agents less toxic and potentially more effective. There is also no doubt that mathematical models for recovery kinetics will play a crucial role in the design of experiments for the testing of various hypotheses regarding the cellular effects of therapeutic agents." @default.
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- W81055650 date "1976-01-01" @default.
- W81055650 modified "2023-09-27" @default.
- W81055650 title "Cell synchronization in vivo: fact or fancy" @default.
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