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- W810710632 abstract "AIM: To investigate the immunoenhancing activity of ginsenoside-F3 in murine spleen cells and explore its mechanism.METHODS: The enhancing effect of ginsenoside-F3 on murine spleen cell proliferation was studied using [^3H]thymidine incorporation assay. Effects of ginsenoside-F3 on the production of type 1 cytokines IL-2, IFN-γ, andtype 2 cytokines IL-4 and IL-10 from murine spleen cells were detected by ELISA method. Effects of ginsenoside-F3 on mRNA level of cytokines IL-4, IFN-γ, and transcription factors T-bet and GATA-3 were evaluated by RT-PCR analysis. Effect of ginsenoside-F3 on NF-rd3 DNA binding activity in murine spleen cells was investigated byelectrophoretic mobility shift assays (EMSA). RESULTS: Ginsenoside-F3 at 0.1-100 μmol/L not only promotedthe murine spleen cell proliferation, but also increased the production of IL-2 and IFN-γ, while decreased theproduction of IL-4 and IL-10 from murine spleen cells with the maximal effect at 10 μmol/L. RT-PCR analysisdisplayed that ginsenoside-F3 enhanced the IFN-γ and T-bet gene expression and decreased IL-4 and GATA-3 geneexpression. EMSA experiment showed that ginsenoside-F3 10 μmol/L enhanced the NF-rd3 DNA binding activityinduced by ConA in murine spleen cells. CONCLUSION: Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1 cytokines and type 2 cytokines in murine spleen cells." @default.
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- W810710632 date "2004-01-01" @default.
- W810710632 modified "2023-09-23" @default.
- W810710632 title "Immunoenhancing activity of protopanaxatriol-type ginsenoside-F3 in murine spleen cells" @default.
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