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• W81118378 abstract "IntroductionPatients with Chronic Kidney Disease (CKD) are at increased risk of both cardiovascular disease and progression to end-stage kidney disease; our understanding of the factors that determine these poor outcomes is incomplete. The study reported in this thesis has been designed to address some of these shortfalls.MethodsI established a prospective, observational cohort study of patients with high risk CKD as defined by i) declining kidney function and/or ii) proteinuria and/or iii) advanced (stage 4 and 5) CKD. Participants undergo repeated detailed bio-clinical assessment over a follow up period of ten years and are tracked for clinical outcomes. The baseline data are presented in this thesis along with some data form the six-month visit.ResultsI report cross-sectional data from the first 500 participants; mean age is 65 years, 60% were male and 72% white ethnicity. Mean eGFR was 27mL/min/1.73m2 and median urine ACR was 26.9 mg/mmol. Detailed analyses demonstrated important associations between i) quality of life and unemployment, male gender, deprivation, co-morbidity and inflammation ii) arterial stiffness, inflammation and renal and cardiovascular outcomes iii) periodontitis and arterial stiffness iv) mortality, inflammation and arterial stiffness.ConclusionsThis thesis reports important new findings from patients with CKD and establishes a resource that will provide future insights that should contribute to improving clinical outcomes." @default.
• W81118378 created "2016-06-24" @default.
• W81118378 creator A5069881619 @default.
• W81118378 date "2013-12-01" @default.
• W81118378 modified "2023-09-23" @default.
• W81118378 title "Establishing a high risk CKD cohort: cross-sectional analysis and early outcomes" @default.
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