FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W81211495> ?p ?o ?g. }

• W81211495 abstract "Background: Visceral abdominal tissue (VAT) is a unique pathogenic fat depot that is associated with cardiometabolic risk above and beyond overall body mass index (BMI). Higher lipid content of adipose tissue is associated with lower tissue attenuation (i.e. more negative) in computed tomography (CT) and is expressed as Hounsfield units (HU). Given this framework, we hypothesized that lower CT attenuation of adipose tissue is associated with more adverse metabolic risk. Methods: Framingham Heart Study participants (n=3198, mean age 51 years, 47% women) who participated in a computed tomography sub-study with volumetrically assessed VAT and documented HU were studied. Cardiovascular risk factors were measured using standard definitions. The association between HU and metabolic risk factors was assessed using sex-specific multivariable-adjusted regression models. Results: Mean visceral HU was −93.9 (Range −105.7 to −79.0). Mean HU were overall lower in men (−95.2) than women (−92.4). Lower HU correlated with higher BMI levels in women (age adjusted r = −0.51, p<0.001) and men (age adjusted r = −0.42, p<0.001). Risk factors levels were more adverse with decreasing HU levels. For example, the age-adjusted prevalence of metabolic syndrome ranged from 50% in the lowest negative tertile of visceral HU to 5.5% in the least negative tertile in women (p for trend across tertiles <0.001) with similar trends observed in men (p<0.001). In women, per 1 standard deviation (SD) decrease in visceral HU, the odds ratio (OR) for metabolic syndrome was 3.6 (95% CI 3.1 to 4.3, p<0.001), which persisted after adjustment for BMI (OR 2.5, p<0.001) and VAT (OR 1.5, p<0.001). Also in women, 1-SD decrease in visceral HU was associated with increased odds of hypertension (OR 1.8, 95% CI 1.6 to 2.1, p<0.001), impaired fasting glucose (OR 2.1, 95% CI 1.8 to 2.4, p<0.001) and insulin resistance (OR 3.3, 95% CI 2.8 to 4.0, p<0.001). These associations remained significant after adjustment for BMI (OR 1.4 to 2.3, all p<0.001). After adjustment for VAT, impaired fasting glucose (OR 1.5, p<0.001) and insulin resistance (OR 1.4, p=0.003) remained associated but hypertension did not (OR 1.2, p=0.19). Finally, per 1-SD decrease in visceral HU, HDL levels were 5.2 mg/dL lower (p <0.001) and log triglycerides were 0.20 mg/dL higher (p<0.001), both of which persisted after VAT adjustment. Similar findings were observed in men. Conclusion: Lower CT attenuation of visceral fat, a marker of higher lipid content of adipose tissue, is associated with increased adverse metabolic risk above and beyond total VAT volume. These findings highlight that both quantity and quality of fat depots may provide additional information regarding cardiometabolic risk." @default.
• W81211495 created "2016-06-24" @default.
• W81211495 creator A5008596377 @default.
• W81211495 creator A5014162614 @default.
• W81211495 creator A5018611179 @default.
• W81211495 creator A5024590816 @default.
• W81211495 creator A5038663858 @default.
• W81211495 creator A5056798958 @default.
• W81211495 date "2012-03-13" @default.
• W81211495 modified "2023-10-17" @default.
• W81211495 title "Abstract MP035: Relative Attenuation of Visceral Adipose Tissue and Metabolic Risk: The Framingham Heart Study" @default.
• W81211495 doi "https://doi.org/10.1161/circ.125.suppl_10.amp035" @default.
• W81211495 hasPublicationYear "2012" @default.
• W81211495 type Work @default.
• W81211495 sameAs 81211495 @default.
• W81211495 citedByCount "0" @default.
• W81211495 crossrefType "journal-article" @default.
• W81211495 hasAuthorship W81211495A5008596377 @default.
• W81211495 hasAuthorship W81211495A5014162614 @default.
• W81211495 hasAuthorship W81211495A5018611179 @default.
• W81211495 hasAuthorship W81211495A5024590816 @default.
• W81211495 hasAuthorship W81211495A5038663858 @default.
• W81211495 hasAuthorship W81211495A5056798958 @default.
• W81211495 hasConcept C111815664 @default.
• W81211495 hasConcept C11783203 @default.
• W81211495 hasConcept C126322002 @default.
• W81211495 hasConcept C134018914 @default.
• W81211495 hasConcept C141071460 @default.
• W81211495 hasConcept C156957248 @default.
• W81211495 hasConcept C164705383 @default.
• W81211495 hasConcept C171089720 @default.
• W81211495 hasConcept C187954543 @default.
• W81211495 hasConcept C2777391703 @default.
• W81211495 hasConcept C2779134260 @default.
• W81211495 hasConcept C2780221984 @default.
• W81211495 hasConcept C2780578515 @default.
• W81211495 hasConcept C2909124604 @default.
• W81211495 hasConcept C3020796190 @default.
• W81211495 hasConcept C511355011 @default.
• W81211495 hasConcept C544519230 @default.
• W81211495 hasConcept C71924100 @default.
• W81211495 hasConceptScore W81211495C111815664 @default.
• W81211495 hasConceptScore W81211495C11783203 @default.
• W81211495 hasConceptScore W81211495C126322002 @default.
• W81211495 hasConceptScore W81211495C134018914 @default.
• W81211495 hasConceptScore W81211495C141071460 @default.
• W81211495 hasConceptScore W81211495C156957248 @default.
• W81211495 hasConceptScore W81211495C164705383 @default.
• W81211495 hasConceptScore W81211495C171089720 @default.
• W81211495 hasConceptScore W81211495C187954543 @default.
• W81211495 hasConceptScore W81211495C2777391703 @default.
• W81211495 hasConceptScore W81211495C2779134260 @default.
• W81211495 hasConceptScore W81211495C2780221984 @default.
• W81211495 hasConceptScore W81211495C2780578515 @default.
• W81211495 hasConceptScore W81211495C2909124604 @default.
• W81211495 hasConceptScore W81211495C3020796190 @default.
• W81211495 hasConceptScore W81211495C511355011 @default.
• W81211495 hasConceptScore W81211495C544519230 @default.
• W81211495 hasConceptScore W81211495C71924100 @default.
• W81211495 hasIssue "suppl_10" @default.
• W81211495 hasLocation W812114951 @default.
• W81211495 hasOpenAccess W81211495 @default.
• W81211495 hasPrimaryLocation W812114951 @default.
• W81211495 hasRelatedWork W1564800354 @default.
• W81211495 hasRelatedWork W1989400130 @default.
• W81211495 hasRelatedWork W2031466315 @default.
• W81211495 hasRelatedWork W2112569577 @default.
• W81211495 hasRelatedWork W2150548541 @default.
• W81211495 hasRelatedWork W2414850025 @default.
• W81211495 hasRelatedWork W2527345173 @default.
• W81211495 hasRelatedWork W2792284970 @default.
• W81211495 hasRelatedWork W2920625688 @default.
• W81211495 hasRelatedWork W81211495 @default.
• W81211495 hasVolume "125" @default.
• W81211495 isParatext "false" @default.
• W81211495 isRetracted "false" @default.
• W81211495 magId "81211495" @default.
• W81211495 workType "article" @default.