Matches in SemOpenAlex for { <https://semopenalex.org/work/W812779980> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W812779980 abstract "Statins improve cardiovascular (CV) status of diabetic patients, regardless of their cholesterol levels. It remains unclear whether this effect is drug-specific or class-dependent,and the underlying mechanisms involved. We compared the effects of a low dose (10 mg/kg/day) of atorvastatin (AV), simvastatin (SV), and pravastatin (PV) over a four-week period on cardiac performance in streptozotocin-induced diabetic rats. Age-matched, non-diabetic rats were used as controls (CT). Echocardiographic variables, systolic blood pressure (SBP), acetylcholine (ACh)-induced relaxation, plasma cholesterol levels, perivascular fibrosis, and oxidative-stress markers MDA and 4-HAE were measured. Cholesterol levels (mg/dl) were higher in diabetic rats than in CT (248.68 ± 15.78 vs. 156.01 ± 7.32, n = 8, P<0.05), and were not modified by any statin at this low dose. All three statins significantly reduced SBP in diabetic rats. Ejection fraction, stroke volume, and cardiac output index were lower in untreated diabetic rats than in CT (n = 10, P<0.05). All three statins significantly increased these CV parameters (n = 10, P<0.05). In addition, statins improved EMax values for the ACh-induced relaxation, decreased media thickness, perivascular fibrosis, and both MDA and 4-HAE in the aortas of diabetic rats. Together, our results indicate that in diabetic rats, AV, SV, and PV are equally effective in improving CV performance. The observed hemodynamic benefits are cholesterol-independent, and appear to be secondary to improved endothelial function, and to reduced vascular tone and remodeling resulting from decreased oxidative stress. Supported by MBRS-RISE R25-GM061838." @default.
- W812779980 created "2016-06-24" @default.
- W812779980 creator A5021171413 @default.
- W812779980 creator A5074366819 @default.
- W812779980 creator A5078973603 @default.
- W812779980 date "2015-04-01" @default.
- W812779980 modified "2023-10-16" @default.
- W812779980 title "Simvastatin, Atorvastatin, and Pravastatin Equally Improve Cardiovascular Status in Diabetic Rats by Improving Endothelial Function, and Reducing Perivascular Fibrosis and Oxidative Stress" @default.
- W812779980 doi "https://doi.org/10.1096/fasebj.29.1_supplement.626.2" @default.
- W812779980 hasPublicationYear "2015" @default.
- W812779980 type Work @default.
- W812779980 sameAs 812779980 @default.
- W812779980 citedByCount "0" @default.
- W812779980 crossrefType "journal-article" @default.
- W812779980 hasAuthorship W812779980A5021171413 @default.
- W812779980 hasAuthorship W812779980A5074366819 @default.
- W812779980 hasAuthorship W812779980A5078973603 @default.
- W812779980 hasConcept C111566952 @default.
- W812779980 hasConcept C126322002 @default.
- W812779980 hasConcept C134018914 @default.
- W812779980 hasConcept C2776151105 @default.
- W812779980 hasConcept C2776329913 @default.
- W812779980 hasConcept C2776839432 @default.
- W812779980 hasConcept C2777180221 @default.
- W812779980 hasConcept C2777482532 @default.
- W812779980 hasConcept C2778163477 @default.
- W812779980 hasConcept C2778198053 @default.
- W812779980 hasConcept C2779519902 @default.
- W812779980 hasConcept C2780559512 @default.
- W812779980 hasConcept C2780972559 @default.
- W812779980 hasConcept C555293320 @default.
- W812779980 hasConcept C71924100 @default.
- W812779980 hasConceptScore W812779980C111566952 @default.
- W812779980 hasConceptScore W812779980C126322002 @default.
- W812779980 hasConceptScore W812779980C134018914 @default.
- W812779980 hasConceptScore W812779980C2776151105 @default.
- W812779980 hasConceptScore W812779980C2776329913 @default.
- W812779980 hasConceptScore W812779980C2776839432 @default.
- W812779980 hasConceptScore W812779980C2777180221 @default.
- W812779980 hasConceptScore W812779980C2777482532 @default.
- W812779980 hasConceptScore W812779980C2778163477 @default.
- W812779980 hasConceptScore W812779980C2778198053 @default.
- W812779980 hasConceptScore W812779980C2779519902 @default.
- W812779980 hasConceptScore W812779980C2780559512 @default.
- W812779980 hasConceptScore W812779980C2780972559 @default.
- W812779980 hasConceptScore W812779980C555293320 @default.
- W812779980 hasConceptScore W812779980C71924100 @default.
- W812779980 hasIssue "S1" @default.
- W812779980 hasLocation W8127799801 @default.
- W812779980 hasOpenAccess W812779980 @default.
- W812779980 hasPrimaryLocation W8127799801 @default.
- W812779980 hasRelatedWork W1971831013 @default.
- W812779980 hasRelatedWork W2013831157 @default.
- W812779980 hasRelatedWork W2016233706 @default.
- W812779980 hasRelatedWork W2029525484 @default.
- W812779980 hasRelatedWork W2037663465 @default.
- W812779980 hasRelatedWork W2041727321 @default.
- W812779980 hasRelatedWork W2124210552 @default.
- W812779980 hasRelatedWork W2152065670 @default.
- W812779980 hasRelatedWork W2885839802 @default.
- W812779980 hasRelatedWork W3123405990 @default.
- W812779980 hasVolume "29" @default.
- W812779980 isParatext "false" @default.
- W812779980 isRetracted "false" @default.
- W812779980 magId "812779980" @default.
- W812779980 workType "article" @default.