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- W81279641 endingPage "110" @default.
- W81279641 startingPage "97" @default.
- W81279641 abstract "Alpha E beta 7 (αEβ7) is an α-I domain-containing integrin that is highly expressed by a variety of leukocyte populations at mucosal sites including intraepithelial T cells, dendritic cells, mast cells, and T regulatory cells (Treg). Expression depends largely or solely on transforming growth factor beta (TGF-β) isoforms. The best characterized ligand for αEβ7 is E-cadherin on epithelial cells, though there is evidence of a second ligand in the human system. An exposed acidic residue on the distal aspect of E-cadherin domain 1 interacts with the MIDAS site in the αE α-I domain. By binding to E-cadherin, αEβ7 contributes to mucosal specific retention of leukocytes within epithelia. Studies on αE knockout mice have identified an additional important function for this integrin in allograft rejection and have also indicated that it may have a role in immunoregulation. Recent studies point to a multifaceted role for αEβ7 in regulating both innate and acquired immune responses to foreign antigen." @default.
- W81279641 created "2016-06-24" @default.
- W81279641 creator A5055726158 @default.
- W81279641 creator A5087774686 @default.
- W81279641 date "2014-01-01" @default.
- W81279641 modified "2023-10-04" @default.
- W81279641 title "Integrin αEβ7: Molecular Features and Functional Significance in the Immune System" @default.
- W81279641 cites W1501511128 @default.
- W81279641 cites W1505295072 @default.
- W81279641 cites W1516764906 @default.
- W81279641 cites W1535141082 @default.
- W81279641 cites W1536714890 @default.
- W81279641 cites W1540243713 @default.
- W81279641 cites W1549505214 @default.
- W81279641 cites W1571142361 @default.
- W81279641 cites W1572760335 @default.
- W81279641 cites W1583728224 @default.
- W81279641 cites W1611284225 @default.
- W81279641 cites W1619186743 @default.
- W81279641 cites W1645337427 @default.
- W81279641 cites W1661414253 @default.
- W81279641 cites W1686260684 @default.
- W81279641 cites W1884519552 @default.
- W81279641 cites W1886019326 @default.
- W81279641 cites W1902157155 @default.
- W81279641 cites W1915418173 @default.
- W81279641 cites W1923708602 @default.
- W81279641 cites W1954748479 @default.
- W81279641 cites W1964010927 @default.
- W81279641 cites W1967586591 @default.
- W81279641 cites W1970379493 @default.
- W81279641 cites W1974092965 @default.
- W81279641 cites W1975163371 @default.
- W81279641 cites W1976150028 @default.
- W81279641 cites W1977102542 @default.
- W81279641 cites W1977940612 @default.
- W81279641 cites W1978187637 @default.
- W81279641 cites W1980708508 @default.
- W81279641 cites W1980942129 @default.
- W81279641 cites W1985631934 @default.
- W81279641 cites W1993531725 @default.
- W81279641 cites W1994799794 @default.
- W81279641 cites W1995955147 @default.
- W81279641 cites W1996229570 @default.
- W81279641 cites W1999227421 @default.
- W81279641 cites W1999283406 @default.
- W81279641 cites W2000403951 @default.
- W81279641 cites W2002502609 @default.
- W81279641 cites W2002681912 @default.
- W81279641 cites W2002774826 @default.
- W81279641 cites W2003098115 @default.
- W81279641 cites W2005627787 @default.
- W81279641 cites W2009968947 @default.
- W81279641 cites W2010023007 @default.
- W81279641 cites W2012286708 @default.
- W81279641 cites W2012364722 @default.
- W81279641 cites W2013479589 @default.
- W81279641 cites W2016836061 @default.
- W81279641 cites W2022225386 @default.
- W81279641 cites W2023571876 @default.
- W81279641 cites W2024263435 @default.
- W81279641 cites W2028134580 @default.
- W81279641 cites W2029184793 @default.
- W81279641 cites W2033018213 @default.
- W81279641 cites W2035774424 @default.
- W81279641 cites W2036353761 @default.
- W81279641 cites W2038536235 @default.
- W81279641 cites W2040272267 @default.
- W81279641 cites W2042142710 @default.
- W81279641 cites W2042387365 @default.
- W81279641 cites W2045848719 @default.
- W81279641 cites W2049387694 @default.
- W81279641 cites W2049714690 @default.
- W81279641 cites W2056752410 @default.
- W81279641 cites W2056947996 @default.
- W81279641 cites W2058405544 @default.
- W81279641 cites W2065814874 @default.
- W81279641 cites W2067484054 @default.
- W81279641 cites W2070298322 @default.
- W81279641 cites W2072051141 @default.
- W81279641 cites W2073462909 @default.
- W81279641 cites W2078033330 @default.
- W81279641 cites W2085457353 @default.
- W81279641 cites W2086947735 @default.
- W81279641 cites W2092642136 @default.
- W81279641 cites W2100932704 @default.
- W81279641 cites W2105959554 @default.
- W81279641 cites W2110957620 @default.
- W81279641 cites W2113168577 @default.
- W81279641 cites W2117084942 @default.
- W81279641 cites W2119359657 @default.
- W81279641 cites W2121726659 @default.
- W81279641 cites W2122639455 @default.
- W81279641 cites W2123460047 @default.
- W81279641 cites W2127051171 @default.
- W81279641 cites W2128382906 @default.
- W81279641 cites W2129127258 @default.
- W81279641 cites W2131014265 @default.