FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W813362938> ?p ?o ?g. }

• W813362938 abstract "Healthcare providers and policy makers are faced with an ever-increasing number of medical publications. Searching for relevant information and keeping up to date with new research findings remains a constant challenge. It has been widely acknowledged that narrative reviews of the literature are susceptible to several types of bias and a systematic approach may protect against these biases. The aim of this thesis was to apply quantitative methods in the assessment of outcomes of topical therapies for psoriasis. In particular, to systematically examine the comparative efficacy, tolerability and cost-effectiveness of topical calcipotriol in the treatment of mild-to-moderate psoriasis. Over the years, a wide range of techniques have been used to evaluate the severity of psoriasis and the outcomes from treatment. This lack of standardisation complicates the direct comparison of results and ultimately the pooling of outcomes from different clinical trials. There is a clear requirement for more comprehensive tools for measuring drug efficacy and disease severity in psoriasis. Ideally, the outcome measures need to be simple, relevant, practical, and widely applicable, and the instruments should be reliable, valid and responsive. The results of the meta-analysis reported herein show that calcipotriol is an effective antipsoriatic agent. In the short-tenn, the pooled data found calcipotriol to be more effective than calcitriol, tacalcitol, coal tar and short-contact dithranol. Only potent corticosteroids appeared to have comparable efficacy, with less short-term side-effects. Potent corticosteroids also added to the antipsoriatic effect of calcipotriol, and appeared to suppress the occurrence of calcipotriol-induced irritation. There was insufficient evidence to support any large effects in favour of improvements in efficacy when calcipotriol is used in combination with systemic therapies in patients with severe psoriasis. However, there was a total absence of long-term morbidity data on the effectiveness of any of the interventions studied. Decision analysis showed that, from the perspective of the NHS as payer, the relatively small differences in efficacy between calcipotriol and short-contact dithranol lead to large differences in the direct cost of treating patients with mildto-moderate plaque psoriasis. Further research is needed to examine the clinical and economic issues affecting patients under treatment for psoriasis in the UK. In particular, the maintenance value and cost/benefit ratio for the various treatment strategies, and the assessment of patient's preferences has not yet been adequately addressed for this chronic recurring disease." @default.
• W813362938 created "2016-06-24" @default.
• W813362938 creator A5005808294 @default.
• W813362938 date "1999-12-01" @default.
• W813362938 modified "2023-09-23" @default.
• W813362938 title "Applying quantitative methods in the assessment of outcomes of pharmacotherapy of psoriasis" @default.
• W813362938 hasPublicationYear "1999" @default.
• W813362938 type Work @default.
• W813362938 sameAs 813362938 @default.
• W813362938 citedByCount "0" @default.
• W813362938 crossrefType "dissertation" @default.
• W813362938 hasAuthorship W813362938A5005808294 @default.
• W813362938 hasConcept C126322002 @default.
• W813362938 hasConcept C16005928 @default.
• W813362938 hasConcept C177713679 @default.
• W813362938 hasConcept C197934379 @default.
• W813362938 hasConcept C2776009542 @default.
• W813362938 hasConcept C2778375690 @default.
• W813362938 hasConcept C2779306117 @default.
• W813362938 hasConcept C2780564577 @default.
• W813362938 hasConcept C2781463552 @default.
• W813362938 hasConcept C535046627 @default.
• W813362938 hasConcept C71924100 @default.
• W813362938 hasConcept C98274493 @default.
• W813362938 hasConceptScore W813362938C126322002 @default.
• W813362938 hasConceptScore W813362938C16005928 @default.
• W813362938 hasConceptScore W813362938C177713679 @default.
• W813362938 hasConceptScore W813362938C197934379 @default.
• W813362938 hasConceptScore W813362938C2776009542 @default.
• W813362938 hasConceptScore W813362938C2778375690 @default.
• W813362938 hasConceptScore W813362938C2779306117 @default.
• W813362938 hasConceptScore W813362938C2780564577 @default.
• W813362938 hasConceptScore W813362938C2781463552 @default.
• W813362938 hasConceptScore W813362938C535046627 @default.
• W813362938 hasConceptScore W813362938C71924100 @default.
• W813362938 hasConceptScore W813362938C98274493 @default.
• W813362938 hasLocation W8133629381 @default.
• W813362938 hasOpenAccess W813362938 @default.
• W813362938 hasPrimaryLocation W8133629381 @default.
• W813362938 hasRelatedWork W1555962450 @default.
• W813362938 hasRelatedWork W1985780399 @default.
• W813362938 hasRelatedWork W2003475832 @default.
• W813362938 hasRelatedWork W2029375786 @default.
• W813362938 hasRelatedWork W2056799009 @default.
• W813362938 hasRelatedWork W2079277436 @default.
• W813362938 hasRelatedWork W2153431006 @default.
• W813362938 hasRelatedWork W2275181293 @default.
• W813362938 hasRelatedWork W2409899079 @default.
• W813362938 hasRelatedWork W2413441086 @default.
• W813362938 hasRelatedWork W2418552322 @default.
• W813362938 hasRelatedWork W2466788013 @default.
• W813362938 hasRelatedWork W2470640312 @default.
• W813362938 hasRelatedWork W2781669731 @default.
• W813362938 hasRelatedWork W2796382123 @default.
• W813362938 hasRelatedWork W2803660120 @default.
• W813362938 hasRelatedWork W2914302947 @default.
• W813362938 hasRelatedWork W2942988576 @default.
• W813362938 hasRelatedWork W34159062 @default.
• W813362938 hasRelatedWork W2413586491 @default.
• W813362938 isParatext "false" @default.
• W813362938 isRetracted "false" @default.
• W813362938 magId "813362938" @default.
• W813362938 workType "dissertation" @default.