FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W813749402> ?p ?o ?g. }

• W813749402 endingPage "321" @default.
• W813749402 startingPage "320" @default.
• W813749402 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20061358 RNAi-induced inhibition of beta-catenin or Aurora kinase is associated with specific changes in gene expression in treated cells. Biomarker-driven drug discovery is a systems biology approach that uses such changes in gene expression as screening signatures to identify small molecule inhibitors of these same targets. We have successfully completed independent screens of small molecule libraries against beta-catenin and Aurora kinase signatures using this approach and have discovered a number of active compound families. We have systematically analyzed these hit compounds with a number of relevant secondary assays, in order to identify the most promising candidates from each program for lead selection and optimization. We will demonstrate that this discovery approach yields hit compounds that can inhibit multiple, distinct nodes within each pathway." @default.
• W813749402 created "2016-06-24" @default.
• W813749402 creator A5004057129 @default.
• W813749402 creator A5005897532 @default.
• W813749402 creator A5006528533 @default.
• W813749402 creator A5013574354 @default.
• W813749402 creator A5018389032 @default.
• W813749402 creator A5024085889 @default.
• W813749402 creator A5024175980 @default.
• W813749402 creator A5036766061 @default.
• W813749402 creator A5038220467 @default.
• W813749402 creator A5038686573 @default.
• W813749402 creator A5044374339 @default.
• W813749402 creator A5045091004 @default.
• W813749402 creator A5061728022 @default.
• W813749402 creator A5066086029 @default.
• W813749402 creator A5070112085 @default.
• W813749402 creator A5072887427 @default.
• W813749402 creator A5083706118 @default.
• W813749402 creator A5085712178 @default.
• W813749402 creator A5085893713 @default.
• W813749402 date "2006-04-15" @default.
• W813749402 modified "2023-09-23" @default.
• W813749402 title "Biomarker-driven drug discovery: Identification and characterization of small molecule inhibitors against beta-catenin and Aurora kinase" @default.
• W813749402 hasPublicationYear "2006" @default.
• W813749402 type Work @default.
• W813749402 sameAs 813749402 @default.
• W813749402 citedByCount "0" @default.
• W813749402 crossrefType "journal-article" @default.
• W813749402 hasAuthorship W813749402A5004057129 @default.
• W813749402 hasAuthorship W813749402A5005897532 @default.
• W813749402 hasAuthorship W813749402A5006528533 @default.
• W813749402 hasAuthorship W813749402A5013574354 @default.
• W813749402 hasAuthorship W813749402A5018389032 @default.
• W813749402 hasAuthorship W813749402A5024085889 @default.
• W813749402 hasAuthorship W813749402A5024175980 @default.
• W813749402 hasAuthorship W813749402A5036766061 @default.
• W813749402 hasAuthorship W813749402A5038220467 @default.
• W813749402 hasAuthorship W813749402A5038686573 @default.
• W813749402 hasAuthorship W813749402A5044374339 @default.
• W813749402 hasAuthorship W813749402A5045091004 @default.
• W813749402 hasAuthorship W813749402A5061728022 @default.
• W813749402 hasAuthorship W813749402A5066086029 @default.
• W813749402 hasAuthorship W813749402A5070112085 @default.
• W813749402 hasAuthorship W813749402A5072887427 @default.
• W813749402 hasAuthorship W813749402A5083706118 @default.
• W813749402 hasAuthorship W813749402A5085712178 @default.
• W813749402 hasAuthorship W813749402A5085893713 @default.
• W813749402 hasConcept C104317684 @default.
• W813749402 hasConcept C116834253 @default.
• W813749402 hasConcept C124535831 @default.
• W813749402 hasConcept C137620995 @default.
• W813749402 hasConcept C161624437 @default.
• W813749402 hasConcept C166703698 @default.
• W813749402 hasConcept C184235292 @default.
• W813749402 hasConcept C20552341 @default.
• W813749402 hasConcept C2779425043 @default.
• W813749402 hasConcept C2780035454 @default.
• W813749402 hasConcept C2780808130 @default.
• W813749402 hasConcept C2781197716 @default.
• W813749402 hasConcept C29537977 @default.
• W813749402 hasConcept C30145163 @default.
• W813749402 hasConcept C46111723 @default.
• W813749402 hasConcept C502942594 @default.
• W813749402 hasConcept C54355233 @default.
• W813749402 hasConcept C59822182 @default.
• W813749402 hasConcept C60644358 @default.
• W813749402 hasConcept C67705224 @default.
• W813749402 hasConcept C70721500 @default.
• W813749402 hasConcept C74187038 @default.
• W813749402 hasConcept C86803240 @default.
• W813749402 hasConcept C98274493 @default.
• W813749402 hasConceptScore W813749402C104317684 @default.
• W813749402 hasConceptScore W813749402C116834253 @default.
• W813749402 hasConceptScore W813749402C124535831 @default.
• W813749402 hasConceptScore W813749402C137620995 @default.
• W813749402 hasConceptScore W813749402C161624437 @default.
• W813749402 hasConceptScore W813749402C166703698 @default.
• W813749402 hasConceptScore W813749402C184235292 @default.
• W813749402 hasConceptScore W813749402C20552341 @default.
• W813749402 hasConceptScore W813749402C2779425043 @default.
• W813749402 hasConceptScore W813749402C2780035454 @default.
• W813749402 hasConceptScore W813749402C2780808130 @default.
• W813749402 hasConceptScore W813749402C2781197716 @default.
• W813749402 hasConceptScore W813749402C29537977 @default.
• W813749402 hasConceptScore W813749402C30145163 @default.
• W813749402 hasConceptScore W813749402C46111723 @default.
• W813749402 hasConceptScore W813749402C502942594 @default.
• W813749402 hasConceptScore W813749402C54355233 @default.
• W813749402 hasConceptScore W813749402C59822182 @default.
• W813749402 hasConceptScore W813749402C60644358 @default.
• W813749402 hasConceptScore W813749402C67705224 @default.
• W813749402 hasConceptScore W813749402C70721500 @default.
• W813749402 hasConceptScore W813749402C74187038 @default.
• W813749402 hasConceptScore W813749402C86803240 @default.
• W813749402 hasConceptScore W813749402C98274493 @default.
• W813749402 hasLocation W8137494021 @default.
• W813749402 hasOpenAccess W813749402 @default.

• next