Matches in SemOpenAlex for { <https://semopenalex.org/work/W81384669> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W81384669 abstract "This is a case report series of four patients who exhibited signs and symptoms of acute liver dysfunction during participation in a Phase I trial of a novel non-steroidal anti-inflammatory drug (NSAID) designed to inhibit microsomal prostaglandin synthase 1 (MPGES1). Within one month of trial initiation, all four patients presented with epigastric pain, fatigue, nausea, and increasing liver function tests (LFTs). Two out of four patients required hospitalization, underwent liver biopsies, and were treated with N-acetylcysteine. The remaining two patients were managed as outpatients. Liver biopsies were consistent with drug induced liver injury (DILI). Within three months of stopping the investigational drug, symptoms subsided and LFTs normalized in all patients. This case report series signifies the importance of NSAIDs and novel drug agents in general as potentially hepatotoxic substances, the need for a high level of suspicion of DILI when considering possible etiologies of acute liver failure, and the need for prompt withdrawal of the causative agent in management of patients presenting with DILI." @default.
- W81384669 created "2016-06-24" @default.
- W81384669 creator A5011874638 @default.
- W81384669 creator A5071098192 @default.
- W81384669 creator A5079094501 @default.
- W81384669 date "2013-09-01" @default.
- W81384669 modified "2023-10-03" @default.
- W81384669 title "Trial and error: investigational drug induced liver injury, a case series report." @default.
- W81384669 cites W1976185410 @default.
- W81384669 cites W1989696800 @default.
- W81384669 cites W1995487106 @default.
- W81384669 cites W2120342328 @default.
- W81384669 cites W2146260845 @default.
- W81384669 cites W2165011857 @default.
- W81384669 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3764585" @default.
- W81384669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24052916" @default.
- W81384669 hasPublicationYear "2013" @default.
- W81384669 type Work @default.
- W81384669 sameAs 81384669 @default.
- W81384669 citedByCount "2" @default.
- W81384669 countsByYear W813846692015 @default.
- W81384669 countsByYear W813846692020 @default.
- W81384669 crossrefType "journal-article" @default.
- W81384669 hasAuthorship W81384669A5011874638 @default.
- W81384669 hasAuthorship W81384669A5071098192 @default.
- W81384669 hasAuthorship W81384669A5079094501 @default.
- W81384669 hasConcept C126322002 @default.
- W81384669 hasConcept C137627325 @default.
- W81384669 hasConcept C141071460 @default.
- W81384669 hasConcept C2776637226 @default.
- W81384669 hasConcept C2780035454 @default.
- W81384669 hasConcept C2780580376 @default.
- W81384669 hasConcept C2992208098 @default.
- W81384669 hasConcept C512861765 @default.
- W81384669 hasConcept C71924100 @default.
- W81384669 hasConcept C90924648 @default.
- W81384669 hasConcept C98274493 @default.
- W81384669 hasConceptScore W81384669C126322002 @default.
- W81384669 hasConceptScore W81384669C137627325 @default.
- W81384669 hasConceptScore W81384669C141071460 @default.
- W81384669 hasConceptScore W81384669C2776637226 @default.
- W81384669 hasConceptScore W81384669C2780035454 @default.
- W81384669 hasConceptScore W81384669C2780580376 @default.
- W81384669 hasConceptScore W81384669C2992208098 @default.
- W81384669 hasConceptScore W81384669C512861765 @default.
- W81384669 hasConceptScore W81384669C71924100 @default.
- W81384669 hasConceptScore W81384669C90924648 @default.
- W81384669 hasConceptScore W81384669C98274493 @default.
- W81384669 hasLocation W813846691 @default.
- W81384669 hasOpenAccess W81384669 @default.
- W81384669 hasPrimaryLocation W813846691 @default.
- W81384669 hasRelatedWork W1578923801 @default.
- W81384669 hasRelatedWork W1843112576 @default.
- W81384669 hasRelatedWork W1965308649 @default.
- W81384669 hasRelatedWork W1973399339 @default.
- W81384669 hasRelatedWork W1981965679 @default.
- W81384669 hasRelatedWork W2062847031 @default.
- W81384669 hasRelatedWork W2101629330 @default.
- W81384669 hasRelatedWork W2114675993 @default.
- W81384669 hasRelatedWork W2123167897 @default.
- W81384669 hasRelatedWork W2132439296 @default.
- W81384669 hasRelatedWork W2169393547 @default.
- W81384669 hasRelatedWork W2169441188 @default.
- W81384669 hasRelatedWork W2241172575 @default.
- W81384669 hasRelatedWork W2353408817 @default.
- W81384669 hasRelatedWork W2359211864 @default.
- W81384669 hasRelatedWork W2378744563 @default.
- W81384669 hasRelatedWork W2385017849 @default.
- W81384669 hasRelatedWork W3135355173 @default.
- W81384669 hasRelatedWork W3176192362 @default.
- W81384669 hasRelatedWork W18079405 @default.
- W81384669 isParatext "false" @default.
- W81384669 isRetracted "false" @default.
- W81384669 magId "81384669" @default.
- W81384669 workType "article" @default.