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- W814294887 abstract "ESTABLISHING THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC AMISULPRIDE IN C57BL/6 MICE By Timothy John Donahue A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2012 Major Director: Joseph H. Porter PhD Professor of Psychology Department of Psychology Antipsychotic medications are used to treat schizophrenia. The present study used the drug discrimination paradigm to measure the subjective effects of the atypical antipsychotic amisulpride and to examine the underlying neuropharmacological mechanisms responsible for the discriminative stimulus property of the drug. Male C57BL/6 mice were trained to discriminate 10 mg/kg (-)S amisulpride from vehicle in a two-lever drug discrimination task. A dose effect curve for (-)S amisulpride yielded an ED50 = 1.77 mg/kg 95% CI [1.28, 2.45 mg/kg]. Substitution testing was conducted for the isomer (+)R amisulpride, racemic (±)SR amisulpride, the atypical antipsychotics clozapine, aripiprazole and the typical antipsychotic haloperidol. There was partial substitution for (+)R amisulpride, and full substitution for (±)SR amisulpride with a significant rightward shift in the dose effect curves. Clozapine, aripiprazole, and haloperidol failed to fully substitute with significant rate suppression at the higher doses. These results demonstrated that (-)S amisulpride has a unique discriminative stimulus that differs from other antipsychotic drugs." @default.
- W814294887 created "2016-06-24" @default.
- W814294887 creator A5000500485 @default.
- W814294887 date "2012-01-01" @default.
- W814294887 modified "2023-09-23" @default.
- W814294887 title "ESTABLISHING THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC AMISULPRIDE IN C57BL/6 MICE" @default.
- W814294887 cites W114047989 @default.
- W814294887 cites W12075716 @default.
- W814294887 cites W1482526937 @default.
- W814294887 cites W14947124 @default.
- W814294887 cites W152613797 @default.
- W814294887 cites W155332746 @default.
- W814294887 cites W156525677 @default.
- W814294887 cites W1567262959 @default.
- W814294887 cites W1573555860 @default.
- W814294887 cites W1579155080 @default.
- W814294887 cites W1583920550 @default.
- W814294887 cites W1830187952 @default.
- W814294887 cites W1925492557 @default.
- W814294887 cites W1927413935 @default.
- W814294887 cites W1960419524 @default.
- W814294887 cites W1966092598 @default.
- W814294887 cites W1968081848 @default.
- W814294887 cites W1968757097 @default.
- W814294887 cites W1970209827 @default.
- W814294887 cites W1970814820 @default.
- W814294887 cites W197101518 @default.
- W814294887 cites W1973585912 @default.
- W814294887 cites W1973850878 @default.
- W814294887 cites W1975066441 @default.
- W814294887 cites W1975239113 @default.
- W814294887 cites W1977027245 @default.
- W814294887 cites W1977409830 @default.
- W814294887 cites W1979700184 @default.
- W814294887 cites W1981230560 @default.
- W814294887 cites W1983805722 @default.
- W814294887 cites W1986146440 @default.
- W814294887 cites W1986484493 @default.
- W814294887 cites W1988107925 @default.
- W814294887 cites W1988978158 @default.
- W814294887 cites W1989405621 @default.
- W814294887 cites W1991541280 @default.
- W814294887 cites W1991864608 @default.
- W814294887 cites W1993560189 @default.
- W814294887 cites W1996858839 @default.
- W814294887 cites W1997875783 @default.
- W814294887 cites W1998468146 @default.
- W814294887 cites W2006875943 @default.
- W814294887 cites W2009447429 @default.
- W814294887 cites W2011899741 @default.
- W814294887 cites W2014387288 @default.
- W814294887 cites W2017839315 @default.
- W814294887 cites W2018385636 @default.
- W814294887 cites W2022010680 @default.
- W814294887 cites W2022264424 @default.
- W814294887 cites W2025240330 @default.
- W814294887 cites W2027215444 @default.
- W814294887 cites W2030055666 @default.
- W814294887 cites W2035098833 @default.
- W814294887 cites W2040348034 @default.
- W814294887 cites W2049054322 @default.
- W814294887 cites W2049122418 @default.
- W814294887 cites W2050380914 @default.
- W814294887 cites W2050865855 @default.
- W814294887 cites W2051238722 @default.
- W814294887 cites W2051262942 @default.
- W814294887 cites W2051800385 @default.
- W814294887 cites W2053754882 @default.
- W814294887 cites W2054871351 @default.
- W814294887 cites W2055782708 @default.
- W814294887 cites W2062704469 @default.
- W814294887 cites W2068020515 @default.
- W814294887 cites W2068377101 @default.
- W814294887 cites W2070357412 @default.
- W814294887 cites W2072069319 @default.
- W814294887 cites W2072768866 @default.
- W814294887 cites W2074668691 @default.
- W814294887 cites W2075675414 @default.
- W814294887 cites W2075712526 @default.
- W814294887 cites W2077038577 @default.
- W814294887 cites W2081181656 @default.
- W814294887 cites W2081966018 @default.
- W814294887 cites W2082058677 @default.
- W814294887 cites W2083141645 @default.
- W814294887 cites W2083252023 @default.
- W814294887 cites W2083366232 @default.
- W814294887 cites W2084333965 @default.
- W814294887 cites W2085360366 @default.
- W814294887 cites W2085588350 @default.
- W814294887 cites W2085803090 @default.
- W814294887 cites W2087614780 @default.
- W814294887 cites W2088535213 @default.
- W814294887 cites W2094707535 @default.
- W814294887 cites W2099576957 @default.
- W814294887 cites W2106451693 @default.
- W814294887 cites W2106618895 @default.
- W814294887 cites W2108968692 @default.
- W814294887 cites W2109865728 @default.
- W814294887 cites W2113758182 @default.
- W814294887 cites W2114495485 @default.