FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W814970103> ?p ?o ?g. }

• W814970103 endingPage "409" @default.
• W814970103 startingPage "402" @default.
• W814970103 abstract "Zhi-Zi-Da-Huang decoction (ZZDHD), a classic traditional Chinese medicine (TCM) formula composed of four herbal medicines, has been widely used to treat various hepatobiliary disorders for a long time in China. However, the pharmacological effect of ZZDHD on liver injury with cholestasis is unrevealed.To investigate the hepatoprotective effect of ZZDHD against α-naphthylisothiocyanate (ANIT)-induced liver injury with cholestasis in rats.The rats were intragastrically (i.g.) given ZZDHD at doses of 1, 2 and 4 g/kg (crude drug/body weight) once a day for seven days and treated with ANIT (75 mg/kg via i.g.) to cause liver injury at 12h after the fifth administration. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltranspeptidase (γ-GTP), total bilirubin (TBIL), direct bilirubin (DBIL) and total bile acid (TBA), as well as bile flow were measured at 48 h after ANIT treatment to evaluate the protective effect of ZZDHD. Moreover, the possible protective mechanisms were elucidated by assays of liver enzyme activities and component contents including malondialdehyde (MDA), myeloperoxidase (MPO), lipid peroxide (LPO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT). The biochemical observations were supplemented by histopathological examination. Ultra fast liquid chromatography-mass spectrometry (UFLC-MS) was used for the phytochemical analysis of ZZDHD.The high dose (4 g/kg) and middle dose (2g/kg) of ZZDHD exhibited significant and dose-dependent protective effect on ANIT-induced liver injury with cholestasis by reversing the changes in bile flow, the serum and hepatic enzymes, and histopathology of the liver tissue. Meanwhile, it was found that the low dose (1g/kg) of ZZDHD did not improve the biochemical indexes except serum TBIL, DBIL and TBA, which showed little protective effect. Phytochemical analysis revealed the presence of sixteen compounds in ZZDHD.This study indicates that ZZDHD exerted a hepatoprotective effect on ANIT-induced liver injury with cholestasis in rats, and the mechanism of this activity is possibly related to its antioxidant properties." @default.
• W814970103 created "2016-06-24" @default.
• W814970103 creator A5015309005 @default.
• W814970103 creator A5018082621 @default.
• W814970103 creator A5029831780 @default.
• W814970103 creator A5039915758 @default.
• W814970103 creator A5045539229 @default.
• W814970103 creator A5064021289 @default.
• W814970103 creator A5071121063 @default.
• W814970103 date "2015-08-01" @default.
• W814970103 modified "2023-09-24" @default.
• W814970103 title "Evaluation of the protective effect of Zhi-Zi-da-Huang decoction on acute liver injury with cholestasis induced by α-naphthylisothiocyanate in rats" @default.
• W814970103 cites W1775749144 @default.
• W814970103 cites W1970618850 @default.
• W814970103 cites W1983351182 @default.
• W814970103 cites W1984272679 @default.
• W814970103 cites W1988961339 @default.
• W814970103 cites W1991774590 @default.
• W814970103 cites W2004843028 @default.
• W814970103 cites W2012510350 @default.
• W814970103 cites W2029618864 @default.
• W814970103 cites W2036075903 @default.
• W814970103 cites W2040542516 @default.
• W814970103 cites W2041383311 @default.
• W814970103 cites W2045979060 @default.
• W814970103 cites W2054818658 @default.
• W814970103 cites W2063656978 @default.
• W814970103 cites W2072392193 @default.
• W814970103 cites W2074231627 @default.
• W814970103 cites W2081293464 @default.
• W814970103 cites W2082960617 @default.
• W814970103 cites W2085454278 @default.
• W814970103 cites W2089768249 @default.
• W814970103 cites W2100051004 @default.
• W814970103 cites W2113681412 @default.
• W814970103 cites W2135323418 @default.
• W814970103 cites W2139000389 @default.
• W814970103 cites W2151290478 @default.
• W814970103 cites W2154923817 @default.
• W814970103 cites W2158103448 @default.
• W814970103 cites W2160960781 @default.
• W814970103 doi "https://doi.org/10.1016/j.jep.2015.06.043" @default.
• W814970103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26163196" @default.
• W814970103 hasPublicationYear "2015" @default.
• W814970103 type Work @default.
• W814970103 sameAs 814970103 @default.
• W814970103 citedByCount "15" @default.
• W814970103 countsByYear W8149701032016 @default.
• W814970103 countsByYear W8149701032017 @default.
• W814970103 countsByYear W8149701032018 @default.
• W814970103 countsByYear W8149701032019 @default.
• W814970103 countsByYear W8149701032020 @default.
• W814970103 countsByYear W8149701032022 @default.
• W814970103 countsByYear W8149701032023 @default.
• W814970103 crossrefType "journal-article" @default.
• W814970103 hasAuthorship W814970103A5015309005 @default.
• W814970103 hasAuthorship W814970103A5018082621 @default.
• W814970103 hasAuthorship W814970103A5029831780 @default.
• W814970103 hasAuthorship W814970103A5039915758 @default.
• W814970103 hasAuthorship W814970103A5045539229 @default.
• W814970103 hasAuthorship W814970103A5064021289 @default.
• W814970103 hasAuthorship W814970103A5071121063 @default.
• W814970103 hasConcept C126322002 @default.
• W814970103 hasConcept C160160445 @default.
• W814970103 hasConcept C181199279 @default.
• W814970103 hasConcept C185592680 @default.
• W814970103 hasConcept C190409667 @default.
• W814970103 hasConcept C2775838275 @default.
• W814970103 hasConcept C2776151105 @default.
• W814970103 hasConcept C2776637226 @default.
• W814970103 hasConcept C2777513400 @default.
• W814970103 hasConcept C2778401633 @default.
• W814970103 hasConcept C2778593092 @default.
• W814970103 hasConcept C2778760513 @default.
• W814970103 hasConcept C55493867 @default.
• W814970103 hasConcept C71924100 @default.
• W814970103 hasConcept C98274493 @default.
• W814970103 hasConceptScore W814970103C126322002 @default.
• W814970103 hasConceptScore W814970103C160160445 @default.
• W814970103 hasConceptScore W814970103C181199279 @default.
• W814970103 hasConceptScore W814970103C185592680 @default.
• W814970103 hasConceptScore W814970103C190409667 @default.
• W814970103 hasConceptScore W814970103C2775838275 @default.
• W814970103 hasConceptScore W814970103C2776151105 @default.
• W814970103 hasConceptScore W814970103C2776637226 @default.
• W814970103 hasConceptScore W814970103C2777513400 @default.
• W814970103 hasConceptScore W814970103C2778401633 @default.
• W814970103 hasConceptScore W814970103C2778593092 @default.
• W814970103 hasConceptScore W814970103C2778760513 @default.
• W814970103 hasConceptScore W814970103C55493867 @default.
• W814970103 hasConceptScore W814970103C71924100 @default.
• W814970103 hasConceptScore W814970103C98274493 @default.
• W814970103 hasFunder F4320321001 @default.
• W814970103 hasLocation W8149701031 @default.
• W814970103 hasLocation W8149701032 @default.
• W814970103 hasOpenAccess W814970103 @default.
• W814970103 hasPrimaryLocation W8149701031 @default.
• W814970103 hasRelatedWork W1984149381 @default.

• next