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- W8152874 abstract "Objective To observe the targeting function of folate-conjugated superparamagnetic iron oxide-dopamine (NP-DPA-FA) to hepatoma cells via folate receptor (FR) and the feasibility for surveillance of tumor targeting with MRI. Methods ①At first, the preparation of NP-DPA-FA was completed. ②Microscopic observation with Prussian blue staining and competitive inhibition was performed in Bel-7402 cells. ③Bel-7402 cells and HL-7702 cells were incubated with NP-DPA-FA for 2 h, respectively. Prussian blue staining was performed to observe intracellular irons, while MRI was performed to study the signal intensity of cells. Results Much more intracellular irons were observed in Bel-7402 cells incubated with NP-DPA-FA than those in HL-7702 cells. Few intracellular irons were found in Bel-7402 cells by competitive inhibition. The signal intensity of Bel-7402 cells on T2WI decreased significantly with the exaltation of iron concentration in NP-DPA-FA, while no significant reduction of the signal intensity was found in HL-7702 cells. Conclusion NP-DPA-FA has good targeting ability to Bel-7402 cells in vitro. The cell targeting events could be monitored with MR imaging." @default.
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- W8152874 date "2011-02-20" @default.
- W8152874 modified "2023-09-27" @default.
- W8152874 title "叶酸靶向超顺磁性氧化铁-多巴胺-叶酸纳米复合物的制备及体外MR成像" @default.
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