FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W815463062> ?p ?o ?g. }

• W815463062 abstract "Asparagine (N)-linked glycosylation occurs on 90% of membrane and secretory proteins and drives folding and trafficking along the secretory pathway. The N-glycan can be attached to an N-X-T/S-Y (X,Y ≠ P) consensus site by one of two oligosaccharyltransferase (OST) STT3 enzymatic isoforms either during protein translation (co-translational) or after protein translation has completed (post-translational). While co-translational N-glycosylation is both rapid and efficient, post-translational N-glycosylation occurs on a much slower time scale and, due to competition with protein degradation and forward trafficking, could be detrimental to the success of a peptide heavily reliant on post-translational Nglycosylation. In evidence, mutations in K channel subunits that shift Nglycosylation kinetics have been directly linked to cardiac arrhythmias. My thesis work focuses on identifying primary sequence factors that affect the rate of Nglycosylation. To identify the molecular determinants that dictate whether a consensus site acquires its initial N-glycan during or after protein synthesis, I used short (~ 100-170 aa) type I transmembrane peptides from the KCNE family (E1-E5) of K channel regulatory subunits. The lifetime of these small membrane proteins in the ER translocon is short, which places a significant time constraint on the cotranslational N-glycosylation machinery and increases the resolution between coand post-translational events. Using rapid metabolic pulse-chase experiments vi" @default.
• W815463062 created "2016-06-24" @default.
• W815463062 creator A5008111634 @default.
• W815463062 date "2014-01-01" @default.
• W815463062 modified "2023-09-23" @default.
• W815463062 title "Identification of Molecular Determinants that Shift Co- and Post-Translational N-Glycosylation Kinetics in Type I Transmembrane Peptides: A Dissertation" @default.
• W815463062 cites W109751085 @default.
• W815463062 cites W1496656839 @default.
• W815463062 cites W1522596503 @default.
• W815463062 cites W1556121705 @default.
• W815463062 cites W1562772107 @default.
• W815463062 cites W1566799087 @default.
• W815463062 cites W1584935191 @default.
• W815463062 cites W1587250416 @default.
• W815463062 cites W1590316159 @default.
• W815463062 cites W1668163968 @default.
• W815463062 cites W1700850674 @default.
• W815463062 cites W1765288636 @default.
• W815463062 cites W1771559326 @default.
• W815463062 cites W1852053696 @default.
• W815463062 cites W1885211128 @default.
• W815463062 cites W1947454816 @default.
• W815463062 cites W1949421724 @default.
• W815463062 cites W1964462261 @default.
• W815463062 cites W1966526764 @default.
• W815463062 cites W1967776513 @default.
• W815463062 cites W1968098810 @default.
• W815463062 cites W1968598003 @default.
• W815463062 cites W1970124996 @default.
• W815463062 cites W1973089523 @default.
• W815463062 cites W1979005514 @default.
• W815463062 cites W1979950508 @default.
• W815463062 cites W1981468825 @default.
• W815463062 cites W1981981822 @default.
• W815463062 cites W1983137097 @default.
• W815463062 cites W1985899857 @default.
• W815463062 cites W1987804131 @default.
• W815463062 cites W1988515297 @default.
• W815463062 cites W1989921227 @default.
• W815463062 cites W1992879192 @default.
• W815463062 cites W1992935237 @default.
• W815463062 cites W1993018415 @default.
• W815463062 cites W1994089342 @default.
• W815463062 cites W1994983075 @default.
• W815463062 cites W2002422701 @default.
• W815463062 cites W2006631610 @default.
• W815463062 cites W2007925986 @default.
• W815463062 cites W2011565078 @default.
• W815463062 cites W2011574040 @default.
• W815463062 cites W2011670149 @default.
• W815463062 cites W2011741529 @default.
• W815463062 cites W2015041810 @default.
• W815463062 cites W2018409817 @default.
• W815463062 cites W2019577213 @default.
• W815463062 cites W2019894781 @default.
• W815463062 cites W2019973925 @default.
• W815463062 cites W2021273656 @default.
• W815463062 cites W2022466025 @default.
• W815463062 cites W2023481561 @default.
• W815463062 cites W2024647359 @default.
• W815463062 cites W2025787384 @default.
• W815463062 cites W2028386037 @default.
• W815463062 cites W2030845841 @default.
• W815463062 cites W2031981850 @default.
• W815463062 cites W2032301491 @default.
• W815463062 cites W2034791373 @default.
• W815463062 cites W2039849471 @default.
• W815463062 cites W2040081725 @default.
• W815463062 cites W2040125446 @default.
• W815463062 cites W2040720590 @default.
• W815463062 cites W2044104889 @default.
• W815463062 cites W2045868744 @default.
• W815463062 cites W2046560280 @default.
• W815463062 cites W2046799089 @default.
• W815463062 cites W2047647185 @default.
• W815463062 cites W2048034139 @default.
• W815463062 cites W2048384162 @default.
• W815463062 cites W2048385302 @default.
• W815463062 cites W2049717531 @default.
• W815463062 cites W2050046181 @default.
• W815463062 cites W2050227184 @default.
• W815463062 cites W2050824263 @default.
• W815463062 cites W2054469296 @default.
• W815463062 cites W2057487309 @default.
• W815463062 cites W2062076252 @default.
• W815463062 cites W2062720641 @default.
• W815463062 cites W2063015454 @default.
• W815463062 cites W2066125672 @default.
• W815463062 cites W2066825192 @default.
• W815463062 cites W2068663593 @default.
• W815463062 cites W2072265501 @default.
• W815463062 cites W2075554603 @default.
• W815463062 cites W2077243151 @default.
• W815463062 cites W2077553731 @default.
• W815463062 cites W2077873945 @default.
• W815463062 cites W2081104776 @default.
• W815463062 cites W2082304034 @default.
• W815463062 cites W2083128912 @default.
• W815463062 cites W2084756418 @default.
• W815463062 cites W2088221752 @default.

• next