FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W815516909> ?p ?o ?g. }

• W815516909 endingPage "339" @default.
• W815516909 startingPage "307" @default.
• W815516909 abstract "This chapter focuses on the postgenomic advances, where a functional understanding of the genes and pathways predicted for intermediary metabolism in the Mycobacterium tuberculosis complex has been obtained, as the framework for the chapter. An interesting spectrum of attenuation was obtained, from very slight in mutants with mutations in sulfur amino acid biosynthesis through strongly attenuated for proline, tryptophan, and leucine auxotrophs to lethal deletions that could not be rescued by the addition of amino acids to culture media for aspartokinase and for the aroK gene in the shared part of aromatic amino biosynthesis. The principal carbon sources that are supplied to M. tuberculosis in culture are glucose, glycerol, lipids, and the carbon skeletons of amino acids. Regardless of which are used, they must be both dissimilated, via acetyl-CoA, to provide energy, and assimilated, notably into the copious glycans and lipids that characterize the mycobacteria. The publication of the M. tuberculosis annotated genome sequence has provided the basis for renewed interest in its metabolism. All the annotated genes have been modeled into biochemical pathways, and functional genomics has already provided new insights into its physiology, its regulation, and its relation to virulence. Patterns are already emerging, with genes involved in stress response, lipid catabolism, and anaerobiosis being linked to the persistence of tubercle bacilli. Together with biochemical demonstrations to verify suggested metabolic pathways or confirmation that individual genes encode key enzymes, these approaches provide a powerful weapon against the tubercle bacilli." @default.
• W815516909 created "2016-06-24" @default.
• W815516909 creator A5010868387 @default.
• W815516909 creator A5047974197 @default.
• W815516909 date "2004-12-13" @default.
• W815516909 modified "2023-10-15" @default.
• W815516909 title "General Metabolism and Biochemical Pathways of Tubercle Bacilli" @default.
• W815516909 cites W1016558562 @default.
• W815516909 cites W1192523012 @default.
• W815516909 cites W134828845 @default.
• W815516909 cites W1487272172 @default.
• W815516909 cites W1492471394 @default.
• W815516909 cites W1507315541 @default.
• W815516909 cites W1517556202 @default.
• W815516909 cites W1533426022 @default.
• W815516909 cites W1538862365 @default.
• W815516909 cites W1548770541 @default.
• W815516909 cites W1552054481 @default.
• W815516909 cites W1555551367 @default.
• W815516909 cites W1559851213 @default.
• W815516909 cites W1590795483 @default.
• W815516909 cites W1591161572 @default.
• W815516909 cites W1600329457 @default.
• W815516909 cites W1614868353 @default.
• W815516909 cites W1642015145 @default.
• W815516909 cites W1643004344 @default.
• W815516909 cites W1647692986 @default.
• W815516909 cites W1794035661 @default.
• W815516909 cites W1798947166 @default.
• W815516909 cites W1861199552 @default.
• W815516909 cites W1864461701 @default.
• W815516909 cites W1893857316 @default.
• W815516909 cites W1900378797 @default.
• W815516909 cites W1900628862 @default.
• W815516909 cites W1919468846 @default.
• W815516909 cites W1929200798 @default.
• W815516909 cites W1931234589 @default.
• W815516909 cites W1942505014 @default.
• W815516909 cites W1943619333 @default.
• W815516909 cites W1944107535 @default.
• W815516909 cites W1964750168 @default.
• W815516909 cites W1966200849 @default.
• W815516909 cites W1967528630 @default.
• W815516909 cites W1969846013 @default.
• W815516909 cites W1973089560 @default.
• W815516909 cites W1979849514 @default.
• W815516909 cites W1980873743 @default.
• W815516909 cites W1981823852 @default.
• W815516909 cites W1984981669 @default.
• W815516909 cites W1988482132 @default.
• W815516909 cites W1990953428 @default.
• W815516909 cites W1991513944 @default.
• W815516909 cites W1992232200 @default.
• W815516909 cites W1993262260 @default.
• W815516909 cites W1994404690 @default.
• W815516909 cites W1997831873 @default.
• W815516909 cites W2000251841 @default.
• W815516909 cites W2000551779 @default.
• W815516909 cites W2004893313 @default.
• W815516909 cites W2005753615 @default.
• W815516909 cites W2006994215 @default.
• W815516909 cites W2007097682 @default.
• W815516909 cites W2007359091 @default.
• W815516909 cites W2011491583 @default.
• W815516909 cites W2012282627 @default.
• W815516909 cites W2013055636 @default.
• W815516909 cites W2014224553 @default.
• W815516909 cites W2014578355 @default.
• W815516909 cites W2017472057 @default.
• W815516909 cites W2018683578 @default.
• W815516909 cites W2023746875 @default.
• W815516909 cites W2030982552 @default.
• W815516909 cites W2031206118 @default.
• W815516909 cites W2031723388 @default.
• W815516909 cites W2031782903 @default.
• W815516909 cites W2032550335 @default.
• W815516909 cites W2035846831 @default.
• W815516909 cites W2036546716 @default.
• W815516909 cites W2039927551 @default.
• W815516909 cites W2043952643 @default.
• W815516909 cites W2044575327 @default.
• W815516909 cites W2049163769 @default.
• W815516909 cites W2051254928 @default.
• W815516909 cites W2052791500 @default.
• W815516909 cites W2054906060 @default.
• W815516909 cites W2055300618 @default.
• W815516909 cites W2060776370 @default.
• W815516909 cites W2062383296 @default.
• W815516909 cites W2064589630 @default.
• W815516909 cites W2065903108 @default.
• W815516909 cites W2066354362 @default.
• W815516909 cites W2067065606 @default.
• W815516909 cites W2069463652 @default.
• W815516909 cites W2077547350 @default.
• W815516909 cites W2079460837 @default.
• W815516909 cites W2079767141 @default.
• W815516909 cites W2080973344 @default.
• W815516909 cites W2081024768 @default.

• next