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- W815652103 abstract "The major histocompatibility complex (MHC) is a membrane protein group of central importance in the immune system. It is divided into two main classes, class I and class II. The MHCs are highly polymorphic which is believed to be indication of trans-species polymorphism (TSP). There is TSP when an allele is maintained in two species through a speciation event. The songbirds that I study here belong to the Passerida group, I focus only on MHC class I exon 3 which encodes the peptide binding region of the MHC protein. At the beginning a database was constructed to store all the information from the di_erent species and a web site was created for easier access to the information. The database has 32 species that belong to the group Passerida and all of them were used for checking if there is a TSP. There are some older studies which have found a TSP 6-7 million years ago (MYA)and my aim was to see if I could _nd a TSP even older than that. I checked for TSP in three di_erent ways by: a) creating a MHC tree using only ten random sequences per species, b) creating three subtrees on species with most recent common ancestors 22-30 MYA and c) checking for identical sequences between the species. The species that were sharing identical sequence also showed TSP in the MHC random tree and all of them are diverged until seven MYA. Another interesting results is that there are some TSP which are going back to two speciation events one was 20 MY. The most recent relationship that we found was three MYA between Passer domesticus and Passer hispaniolensis and the oldest one was 28 MYA between Carpodacus erythrinus, Haemorhous mexicanus and Thraupis episcopus. (Less)" @default.
- W815652103 created "2016-06-24" @default.
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- W815652103 date "2015-01-01" @default.
- W815652103 modified "2023-09-27" @default.
- W815652103 title "Evolution of Major Histocompatibility Complex (MHC) Genes in Songbirds" @default.
- W815652103 hasPublicationYear "2015" @default.
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