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• W815874675 startingPage "393" @default.
• W815874675 abstract "As the elucidation of the molecular mechanisms behind quorum sensing (QS) gained momentum, researchers conceived several strategies to block QS systems. Indeed, QS signals can be detected in biofilms across a range of environments. For example, biofilms grown on rocks in the San Marcos River in Texas have been shown to produce acyl-homoserine lactone (AHL) signals, as have biofilm communities on marine snow particles and sponge surfaces. One of the major problems with conventional biofilm-control measures is the development of resistance. The red seaweed Delisea pulchra produces a range of halogenated furanone compounds that display antifouling and antimicrobial properties, altering the abundance and composition of the bacterial community on the surface and hence the subsequent development of a biofouling community. Transcriptomic analysis of gene expression shows that 4-nitro-pyridine-N-oxide (4-NPO) mainly affects genes that are regulated by either RhlR alone or RhlR and LasR in concert. A recent transcriptomic analysis strongly suggests that the wild-type Pseudomonas aeruginosa further activates a QS-controlled strategic defense system, which reacts upon the encounter with polymorphonuclear leukocytes (PMNs) and suppresses the powerful cellular immune response by paralyzing the PMNs. Since the transcriptomic studies of in vitro biofilms suggest the existence of multiple pathways by which a biofilm can be built, the use and administration of QS blocking technologies may undergo further development and be combined with treatments directed at targets in additional pathways instrumental for biofilm development." @default.
• W815874675 created "2016-06-24" @default.
• W815874675 creator A5004988031 @default.
• W815874675 creator A5066354921 @default.
• W815874675 creator A5069938653 @default.
• W815874675 creator A5079156406 @default.
• W815874675 date "2014-04-09" @default.
• W815874675 modified "2023-10-16" @default.
• W815874675 title "Quorum-Sensing Inhibition" @default.
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