Matches in SemOpenAlex for { <https://semopenalex.org/work/W815939712> ?p ?o ?g. }
- W815939712 endingPage "649" @default.
- W815939712 startingPage "644" @default.
- W815939712 abstract "Ethyl and isopropyl cyanoacetates were tested as acylating agents in the kinetic resolution of racemic 1-phenylethanamine rac-1 catalyzed by lipase B from Candida antarctica. The best conversion combined with high enantioselectivity was achieved with ethyl cyanoacetate 2a as the acylating agent and immobilized lipase B from Candida antarctica (CaLB N435) as the biocatalyst. Enantiomers of the amides (R)-3 and (S)-3 were obtained with high enantiopurity (ee >98%) by lipase-catalyzed kinetic resolution and by chemical conversion of the residual (S)-1, respectively. The amides were reacted with various aromatic aldehydes 4a–c,e in Knoevenagel condensation to yield Tyrphostins rac-5a–c,e, (R)-5a–c,e and (S)-5a–c,e, which were tested as protein tyrosine kinase inhibitors on human cancer cell lines HCT 116, A549, PC9, PC9ER, Jurkat, and MV4-11. Although some of the novel Tyrphostins exhibited weak biological activities (EC50 ∼6–60 μM), none of them proved to have a significant effect on the growth of the investigated cell lines." @default.
- W815939712 created "2016-06-24" @default.
- W815939712 creator A5000161901 @default.
- W815939712 creator A5018899975 @default.
- W815939712 creator A5030111395 @default.
- W815939712 creator A5065847232 @default.
- W815939712 creator A5073849664 @default.
- W815939712 creator A5076692484 @default.
- W815939712 date "2015-07-01" @default.
- W815939712 modified "2023-10-18" @default.
- W815939712 title "Chemoenzymatic route to Tyrphostins involving lipase-catalyzed kinetic resolution of 1-phenylethanamine with alkyl cyanoacetates as novel acylating agents" @default.
- W815939712 cites W1652052270 @default.
- W815939712 cites W1976529683 @default.
- W815939712 cites W1979855676 @default.
- W815939712 cites W1981227290 @default.
- W815939712 cites W1982302807 @default.
- W815939712 cites W1985268045 @default.
- W815939712 cites W1987905567 @default.
- W815939712 cites W1999276393 @default.
- W815939712 cites W2001384983 @default.
- W815939712 cites W2009707532 @default.
- W815939712 cites W2039859291 @default.
- W815939712 cites W2042826760 @default.
- W815939712 cites W2043916780 @default.
- W815939712 cites W2047480621 @default.
- W815939712 cites W2048037033 @default.
- W815939712 cites W2057004413 @default.
- W815939712 cites W2058371435 @default.
- W815939712 cites W2085375532 @default.
- W815939712 cites W2093265335 @default.
- W815939712 cites W2109517243 @default.
- W815939712 cites W2117149399 @default.
- W815939712 cites W2120809722 @default.
- W815939712 cites W2122962387 @default.
- W815939712 cites W2151513527 @default.
- W815939712 cites W2156533755 @default.
- W815939712 cites W2160864776 @default.
- W815939712 cites W2168683010 @default.
- W815939712 cites W2178986371 @default.
- W815939712 cites W2332626084 @default.
- W815939712 cites W2950546407 @default.
- W815939712 cites W2951260916 @default.
- W815939712 doi "https://doi.org/10.1016/j.tetasy.2015.04.013" @default.
- W815939712 hasPublicationYear "2015" @default.
- W815939712 type Work @default.
- W815939712 sameAs 815939712 @default.
- W815939712 citedByCount "10" @default.
- W815939712 countsByYear W8159397122016 @default.
- W815939712 countsByYear W8159397122017 @default.
- W815939712 countsByYear W8159397122018 @default.
- W815939712 countsByYear W8159397122019 @default.
- W815939712 countsByYear W8159397122020 @default.
- W815939712 countsByYear W8159397122021 @default.
- W815939712 countsByYear W8159397122023 @default.
- W815939712 crossrefType "journal-article" @default.
- W815939712 hasAuthorship W815939712A5000161901 @default.
- W815939712 hasAuthorship W815939712A5018899975 @default.
- W815939712 hasAuthorship W815939712A5030111395 @default.
- W815939712 hasAuthorship W815939712A5065847232 @default.
- W815939712 hasAuthorship W815939712A5073849664 @default.
- W815939712 hasAuthorship W815939712A5076692484 @default.
- W815939712 hasConcept C146686406 @default.
- W815939712 hasConcept C154881586 @default.
- W815939712 hasConcept C161790260 @default.
- W815939712 hasConcept C168395250 @default.
- W815939712 hasConcept C178790620 @default.
- W815939712 hasConcept C181199279 @default.
- W815939712 hasConcept C185592680 @default.
- W815939712 hasConcept C191503008 @default.
- W815939712 hasConcept C2779542420 @default.
- W815939712 hasConcept C2779697368 @default.
- W815939712 hasConcept C28173026 @default.
- W815939712 hasConcept C3141732 @default.
- W815939712 hasConceptScore W815939712C146686406 @default.
- W815939712 hasConceptScore W815939712C154881586 @default.
- W815939712 hasConceptScore W815939712C161790260 @default.
- W815939712 hasConceptScore W815939712C168395250 @default.
- W815939712 hasConceptScore W815939712C178790620 @default.
- W815939712 hasConceptScore W815939712C181199279 @default.
- W815939712 hasConceptScore W815939712C185592680 @default.
- W815939712 hasConceptScore W815939712C191503008 @default.
- W815939712 hasConceptScore W815939712C2779542420 @default.
- W815939712 hasConceptScore W815939712C2779697368 @default.
- W815939712 hasConceptScore W815939712C28173026 @default.
- W815939712 hasConceptScore W815939712C3141732 @default.
- W815939712 hasIssue "12-13" @default.
- W815939712 hasLocation W8159397121 @default.
- W815939712 hasOpenAccess W815939712 @default.
- W815939712 hasPrimaryLocation W8159397121 @default.
- W815939712 hasRelatedWork W1974200402 @default.
- W815939712 hasRelatedWork W1995099690 @default.
- W815939712 hasRelatedWork W2024461651 @default.
- W815939712 hasRelatedWork W2024641109 @default.
- W815939712 hasRelatedWork W2108180406 @default.
- W815939712 hasRelatedWork W2157112603 @default.
- W815939712 hasRelatedWork W2171261875 @default.
- W815939712 hasRelatedWork W2949747453 @default.
- W815939712 hasRelatedWork W3000622830 @default.