Matches in SemOpenAlex for { <https://semopenalex.org/work/W81623799> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W81623799 endingPage "83" @default.
- W81623799 startingPage "779" @default.
- W81623799 abstract "Determination of the plasma amino acid (AA) levels in Huntington's disease (HD) can make it possible to find the metabolic markers used in early diagnosis. The aim of the presented study was to determine the AA profile in plasma samples from HD patients and presymptomatic carriers, compared to healthy subjects. The AA profile was analyzed with HPLC. The study concerned 59 participants: 30 subjects with abnormal CAG repeats expansion (>36) in the HTT gene, and 29 healthy subjects. Each participant was analyzed with regard to the parameters characterizing the metabolic state and protein metabolism, such as: urea, creatinine, glucose, total protein, TSH (thyroid-stimulating hormone), cortisol, ESR (erythrocyte sedimentation rate), and CRP (C-reactive protein). Simple statistical comparisons showed 5 AA to be significantly lower in the HD group, compared to the control group, i.e.: Asn, His, Leu, Ser, Thr. Creatinine and creatinine clirens were found to be lower in the HD group, compared to controls, while ESR was noticed to be higher. As a result of Canonical Discriminant Analysis, 5 of all AA assayed (Leu, Gln, Asn, Ser and Lys) were selected as variables that allow distinguishing between HD patients and healthy subjects with 75% of correctness. Concerning AA profile and biochemical markers, Canonical Discriminant Analysis detected a panel of variables (Ser, Asn, Gln, Orn, Pro, Arg, Met, Cit, Val, TSH, glucose, urea, creatinine clirens, total protein, cortisol, CRP) distinguishing HD from the control group, with 90% of correctness. Among all the parameters tested, Asn and Ser were revealed in all statistical analyses and could be considered as potential plasma HD biomarkers." @default.
- W81623799 created "2016-06-24" @default.
- W81623799 creator A5000343896 @default.
- W81623799 creator A5015166824 @default.
- W81623799 creator A5028692582 @default.
- W81623799 creator A5029978947 @default.
- W81623799 creator A5047368506 @default.
- W81623799 creator A5069577634 @default.
- W81623799 creator A5080872080 @default.
- W81623799 creator A5087672431 @default.
- W81623799 date "2013-01-01" @default.
- W81623799 modified "2023-09-28" @default.
- W81623799 title "Huntington' disease--imbalance of amino acid levels in plasma of patients and mutation carriers." @default.
- W81623799 cites W1987437287 @default.
- W81623799 cites W1993418561 @default.
- W81623799 cites W1994623271 @default.
- W81623799 cites W2009115851 @default.
- W81623799 cites W2021393181 @default.
- W81623799 cites W2035762281 @default.
- W81623799 cites W2044244805 @default.
- W81623799 cites W2050100903 @default.
- W81623799 cites W2072964715 @default.
- W81623799 cites W2074119273 @default.
- W81623799 cites W2101463846 @default.
- W81623799 cites W2102118295 @default.
- W81623799 cites W2107935380 @default.
- W81623799 cites W2137414549 @default.
- W81623799 cites W2157059809 @default.
- W81623799 cites W2411070845 @default.
- W81623799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24364452" @default.
- W81623799 hasPublicationYear "2013" @default.
- W81623799 type Work @default.
- W81623799 sameAs 81623799 @default.
- W81623799 citedByCount "10" @default.
- W81623799 countsByYear W816237992016 @default.
- W81623799 countsByYear W816237992017 @default.
- W81623799 countsByYear W816237992018 @default.
- W81623799 countsByYear W816237992020 @default.
- W81623799 countsByYear W816237992021 @default.
- W81623799 countsByYear W816237992022 @default.
- W81623799 countsByYear W816237992023 @default.
- W81623799 crossrefType "journal-article" @default.
- W81623799 hasAuthorship W81623799A5000343896 @default.
- W81623799 hasAuthorship W81623799A5015166824 @default.
- W81623799 hasAuthorship W81623799A5028692582 @default.
- W81623799 hasAuthorship W81623799A5029978947 @default.
- W81623799 hasAuthorship W81623799A5047368506 @default.
- W81623799 hasAuthorship W81623799A5069577634 @default.
- W81623799 hasAuthorship W81623799A5080872080 @default.
- W81623799 hasAuthorship W81623799A5087672431 @default.
- W81623799 hasConcept C126322002 @default.
- W81623799 hasConcept C134018914 @default.
- W81623799 hasConcept C185592680 @default.
- W81623799 hasConcept C2778143017 @default.
- W81623799 hasConcept C2780306776 @default.
- W81623799 hasConcept C2780365088 @default.
- W81623799 hasConcept C55493867 @default.
- W81623799 hasConcept C71924100 @default.
- W81623799 hasConcept C86803240 @default.
- W81623799 hasConceptScore W81623799C126322002 @default.
- W81623799 hasConceptScore W81623799C134018914 @default.
- W81623799 hasConceptScore W81623799C185592680 @default.
- W81623799 hasConceptScore W81623799C2778143017 @default.
- W81623799 hasConceptScore W81623799C2780306776 @default.
- W81623799 hasConceptScore W81623799C2780365088 @default.
- W81623799 hasConceptScore W81623799C55493867 @default.
- W81623799 hasConceptScore W81623799C71924100 @default.
- W81623799 hasConceptScore W81623799C86803240 @default.
- W81623799 hasIssue "4" @default.
- W81623799 hasLocation W816237991 @default.
- W81623799 hasOpenAccess W81623799 @default.
- W81623799 hasPrimaryLocation W816237991 @default.
- W81623799 hasRelatedWork W1966504330 @default.
- W81623799 hasRelatedWork W1979139803 @default.
- W81623799 hasRelatedWork W2030889776 @default.
- W81623799 hasRelatedWork W2037631372 @default.
- W81623799 hasRelatedWork W2057552018 @default.
- W81623799 hasRelatedWork W2090960426 @default.
- W81623799 hasRelatedWork W2120489977 @default.
- W81623799 hasRelatedWork W2132898409 @default.
- W81623799 hasRelatedWork W2748952813 @default.
- W81623799 hasRelatedWork W2899084033 @default.
- W81623799 hasVolume "20" @default.
- W81623799 isParatext "false" @default.
- W81623799 isRetracted "false" @default.
- W81623799 magId "81623799" @default.
- W81623799 workType "article" @default.