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- W81662021 abstract "Abstract Csk is a key negative regulator of Src-family kinases and has been shown to be a strong inhibitor of immunoreceptor signalling in T cells and granulocytes. Our hypothesis is that an increase in Src kinase activity might take place in NK cells following the elimination of Csk, resulting in an enhanced cellular response even at low levels of stimulation. We aim to establish the role of Csk in NK cells using conditional knockout mice. A transgenic mouse has been developed where the Csk gene is flanked by LoxP (floxed) sites. Crossing Csk floxed transgenic mice with transgenic mice expressing Cre recombinase under the control of a human CD2 gene (hCD2-iCre) will enable the deletion of the Csk gene in a tissue-specific manner. The ROSA26 reporter gene system suggests that Cre deletes the floxed gene in approximately 30% of splenic NK cells and, as reported before, in the vast majority of T cells and B cells. Intracellular staining for Csk demonstrates a correlation between Cre targeting of the ROSA26 locus and the target locus. There is a reduction in the number of lymphocytes in the Csk knockout (KO) mouse. More specifically, there is a decrease in B cells, suggesting a role for Csk in B cell development. However, no obvious phenotype is detected in NK cells. Ongoing studies of NK cell functions will be presented." @default.
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- W81662021 date "2009-04-01" @default.
- W81662021 modified "2023-09-24" @default.
- W81662021 title "Conditional targeting of C-terminal Src kinase (Csk) in NK cells (135.2)" @default.
- W81662021 doi "https://doi.org/10.4049/jimmunol.182.supp.135.2" @default.
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