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- W817071640 abstract "October 2011.Abstract: Emergence of resistant strains of pathogenic microorganisms has continued to pose major health concern aboutthe efficacy of several antibiotic therapies available in the market today. The search for new and effective antimicrobialsubstances from sources such as plants has become a necessary approach towards overcoming this medical challenge.This study was designed to determine the preliminary phytochemical composition and in vitro antimicrobial properties ofaqueous and methanol extracts of Icacina trichantha Oliv. leaf. The fresh leaves of I. trichantha were collected in Jesse,Delta State, Nigeria cleaned, dried and extracted with distilled water and analytical methanol by maceration method.Standard qualitative screening revealed that the compounds of pharmacological interest present in the plant were alkalo-ids, tannins and saponins. Both extracts showed broad spectrum antimicrobial activities, which were clearly dose depen-dent. However, the methanol extract had preferable activity than corresponding concentrations of the aqueous extract. Inthe agar-well diffusion assay, highest inhibition zone diameters of 25.00 mm and 21.00 mm were recorded with Gram-negative bacteria, Pseudomonas aeruginosa and Escherichia coli respectively. The broth micro-dilution assay gave mi-nimal inhibitory concentration values ranging from 3.125 to 100 mg/ml and minimal bactericidal concentration valuesranging from 6.25 to 100 mg/ml. The methanol extract, at higher concentrations, also compared favorably with peflox-acin, a positive control.Keywords: In vitro; Antimicrobial; Aqueous; Methanol; Extract; Icacina trichantha; Leaf." @default.
- W817071640 created "2016-06-24" @default.
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- W817071640 date "2011-01-01" @default.
- W817071640 modified "2023-09-23" @default.
- W817071640 title "Preliminary phytochemistry and in vitro antimicrobial properties of aqueous and methanol extracts of Icacina trichantha Oliv. leaf." @default.
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