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- W817114927 abstract "By: Salena Meyer Abstract: Ionizing radiation is one of the most commonly used cancer treatments. Radiation can be extremely affective at killing malignant tissue; however, the treatment comes with a wide range of debilitating side effects. A large portion of the side effects due to radiation treatment are a direct result of the radiosensitivity of nearby tissues. The salivary gland is incredibly sensitive to ionizing radiation, and damage to this tissue may result in a drastic decrease in the quality of life of the patient. One way to decrease the side effects of radiation damage to the salivary gland is to activate DNA repair following radiation treatment. Changes in DNA damage of irradiated mice with and without IGF1 (insulin-like growth factor 1) were quantitatively measured over time with a comet assay. DNA repair response following radiation treatment was measured by amounts of γ-H2AX, phospho-RPA, and Sirtuin 1 present in mice at time points corresponding to those used in the comet assay. In mice, we have found that injection of IGF1 prior to radiation treatment results in the same amount of initial DNA damage; however, over time DNA damage quantitatively decreases at time points corresponding to the visual activation of DNA repair." @default.
- W817114927 created "2016-06-24" @default.
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- W817114927 date "2011-05-01" @default.
- W817114927 modified "2023-09-26" @default.
- W817114927 title "Regulation of DNA Repair Following Radiation-Induced Salivary Gland Dysfunction" @default.
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