Matches in SemOpenAlex for { <https://semopenalex.org/work/W81832289> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W81832289 endingPage "189" @default.
- W81832289 startingPage "185" @default.
- W81832289 abstract "Adenylosuccinase (adenylosuccinate lyase, EC 4.3.2.2: ASase) catalyses two steps in the purine metabolic pathways: a) the eighth step in the de novo pathway of purine synthesis: conversion of succinylaminoimidazole carboxamide ribotide (SAICAR) into aminoimidazole carboxamide ribotide (AICAR) and b) the second step in the formation of adenyl nucleotides from IMP: conversion of adenylosuccinate (S-AMP) into AMP. As a result of the enzyme deficiency, there is a recognised accumulation of the two dephosphorylated substrates of the enzyme: SAICA riboside and succinyladenosine (S-Ado). Dephosphorylation of SAICAR and S-AMP is performed by cytosolic 5′nucleotidases. Neither SAICA riboside nor S-Ado are normally detectable in the blood or tissue samples of humans, but in patients with ASase deficiency, both compounds are present in the urine, blood and CSF. In the latter, concentrations are usually around 100-200 μM (Jaeken et al., 1993)." @default.
- W81832289 created "2016-06-24" @default.
- W81832289 creator A5012916525 @default.
- W81832289 creator A5018824903 @default.
- W81832289 creator A5041368448 @default.
- W81832289 creator A5059872351 @default.
- W81832289 creator A5073015039 @default.
- W81832289 creator A5073816426 @default.
- W81832289 creator A5074174039 @default.
- W81832289 creator A5080990739 @default.
- W81832289 creator A5088025499 @default.
- W81832289 creator A5091818593 @default.
- W81832289 date "1998-01-01" @default.
- W81832289 modified "2023-09-27" @default.
- W81832289 title "Succinylpurines Induce Neuronal Damage in the Rat Brain" @default.
- W81832289 cites W1997873485 @default.
- W81832289 cites W2011072584 @default.
- W81832289 cites W2028690554 @default.
- W81832289 cites W2041797039 @default.
- W81832289 cites W2053530407 @default.
- W81832289 cites W2072334018 @default.
- W81832289 cites W4214898948 @default.
- W81832289 cites W54968955 @default.
- W81832289 cites W592854807 @default.
- W81832289 doi "https://doi.org/10.1007/978-1-4615-5381-6_36" @default.
- W81832289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9598056" @default.
- W81832289 hasPublicationYear "1998" @default.
- W81832289 type Work @default.
- W81832289 sameAs 81832289 @default.
- W81832289 citedByCount "20" @default.
- W81832289 countsByYear W818322892013 @default.
- W81832289 countsByYear W818322892014 @default.
- W81832289 countsByYear W818322892015 @default.
- W81832289 countsByYear W818322892019 @default.
- W81832289 countsByYear W818322892020 @default.
- W81832289 countsByYear W818322892022 @default.
- W81832289 countsByYear W818322892023 @default.
- W81832289 crossrefType "book-chapter" @default.
- W81832289 hasAuthorship W81832289A5012916525 @default.
- W81832289 hasAuthorship W81832289A5018824903 @default.
- W81832289 hasAuthorship W81832289A5041368448 @default.
- W81832289 hasAuthorship W81832289A5059872351 @default.
- W81832289 hasAuthorship W81832289A5073015039 @default.
- W81832289 hasAuthorship W81832289A5073816426 @default.
- W81832289 hasAuthorship W81832289A5074174039 @default.
- W81832289 hasAuthorship W81832289A5080990739 @default.
- W81832289 hasAuthorship W81832289A5088025499 @default.
- W81832289 hasAuthorship W81832289A5091818593 @default.
- W81832289 hasConcept C104317684 @default.
- W81832289 hasConcept C169586020 @default.
- W81832289 hasConcept C178666793 @default.
- W81832289 hasConcept C181199279 @default.
- W81832289 hasConcept C181912034 @default.
- W81832289 hasConcept C185592680 @default.
- W81832289 hasConcept C2776328115 @default.
- W81832289 hasConcept C2776476023 @default.
- W81832289 hasConcept C512185932 @default.
- W81832289 hasConcept C55493867 @default.
- W81832289 hasConcept C71615608 @default.
- W81832289 hasConcept C98892162 @default.
- W81832289 hasConceptScore W81832289C104317684 @default.
- W81832289 hasConceptScore W81832289C169586020 @default.
- W81832289 hasConceptScore W81832289C178666793 @default.
- W81832289 hasConceptScore W81832289C181199279 @default.
- W81832289 hasConceptScore W81832289C181912034 @default.
- W81832289 hasConceptScore W81832289C185592680 @default.
- W81832289 hasConceptScore W81832289C2776328115 @default.
- W81832289 hasConceptScore W81832289C2776476023 @default.
- W81832289 hasConceptScore W81832289C512185932 @default.
- W81832289 hasConceptScore W81832289C55493867 @default.
- W81832289 hasConceptScore W81832289C71615608 @default.
- W81832289 hasConceptScore W81832289C98892162 @default.
- W81832289 hasLocation W818322891 @default.
- W81832289 hasLocation W818322892 @default.
- W81832289 hasOpenAccess W81832289 @default.
- W81832289 hasPrimaryLocation W818322891 @default.
- W81832289 hasRelatedWork W1009791730 @default.
- W81832289 hasRelatedWork W1957181770 @default.
- W81832289 hasRelatedWork W1985654998 @default.
- W81832289 hasRelatedWork W2059175100 @default.
- W81832289 hasRelatedWork W2069062978 @default.
- W81832289 hasRelatedWork W2183988656 @default.
- W81832289 hasRelatedWork W2413319058 @default.
- W81832289 hasRelatedWork W2502268632 @default.
- W81832289 hasRelatedWork W81832289 @default.
- W81832289 hasRelatedWork W1555636732 @default.
- W81832289 isParatext "false" @default.
- W81832289 isRetracted "false" @default.
- W81832289 magId "81832289" @default.
- W81832289 workType "book-chapter" @default.