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• W81872523 abstract "The variable-criteria sequential stopping rule (SSR) allows an investigator to use a few subjects at a time to determine whether a planned experiment is worth pursuing without increasing the rate of false discoveries (type I errors). The SSR is appropriate whenever testing a null hypothesis if the experiment can be conducted in stages. The investigator adds a predetermined number of subjects at each stage and tests repeatedly for significance until the experiment is stopped because: (1) a significant effect is detected; (2) the effect is clearly not going to be significant; or (3) the predetermined maximal number of subjects has been reached. Two crucial features of the SSR are that it holds the probability of a type I error constant and maintains excellent power. The method is more efficient than is performing a typical significance test after a power analysis because SSR can require 30% fewer subjects to achieve the same power. The variable-criteria SSR provides a formal method for assuring the use of a minimal number of animals. This article provides practical examples of how to use the SSR in combination with a t test, one-way ANOVA, one-way ANOVA with a planned contrast as the focus of the stopping rule, or, in limited circumstances, multifactorial ANOVA." @default.
• W81872523 created "2016-06-24" @default.
• W81872523 creator A5080509770 @default.
• W81872523 date "2011-06-01" @default.
• W81872523 modified "2023-09-23" @default.
• W81872523 title "Minimizing animal numbers: the variable-criteria sequential stopping rule." @default.
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• W81872523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3123753" @default.
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