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- W81933919 abstract "Zileuton, a leukotriene inhibitor used to treat asthma, is usually administered via the oral route. A transdermal drug delivery system for zileuton was developed for this study. A vertical diffusion cell and freshly harvested human skin were used to test the system. Thirteen percent (3.3mg) of the drug was delivered into the dermis within 24 hours, and 13.6% (3.3 mg) of the drug was delivered through the epidermis into the receiving chamber of the diffusion cell within 24 hours. A specially constructed transdermal zileuton gel delivered 13.1% (3.3 mg) of the drug through the epidermis into the receiving chamber within 24 hours. These results are predictive of the successful use of zileuton as a transdermal gel in human subjects." @default.
- W81933919 created "2016-06-24" @default.
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- W81933919 date "2006-09-01" @default.
- W81933919 modified "2023-09-23" @default.
- W81933919 title "In vitro transdermal diffusion of zileuton from a topical gel." @default.
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