FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W819417883> ?p ?o ?g. }

• W819417883 abstract "Many of the cardiovascular-related adaptations that occur in the microgravity environment are due, in part, to a well-characterized cephalad-fluid shift that is evidenced by facial edema and decreased lower limb circumference. It is believed that most of these alterations occur as a compensatory response necessary to maintain a normal blood pressure and cardiac output while in space. However, data from both flight and analog research suggest that in some instances these microgravity-induced alterations may contribute to cardiovascular-related pathologies. Most concerning is the potential relation between the vision disturbances experienced by some long duration crewmembers and changes in cerebral blood flow and intra-ocular pressure. The purpose of this project was to identify cardiovascular measures that may potentially distinguish individuals at risk for visual disturbances after long duration space flight. Toward this goal, we constructed a dataset from Medical Operation tilt/stand test evaluations pre- (days L-15-L-5) and immediate post-flight (day R+0) on 20 (3 females, 17 males). We restricted our evaluation to only crewmembers who participated in both shuttle and space station missions. Data analysis was performed using both descriptive and analytical methods (Stata 11.2, College Station, TX) and are presented as means +/- 95% CI. Crewmembers averaged 5207 (3447 - 8934) flight hours across both long (MIR-23 through Expedition16) and short (STS-27 through STS-101) duration missions between 1988 and 2008. The mean age of the crew at the time of their most recent shuttle flight was 41 (34-44) compared to 47 (40-54) years during their time on station. In order to focus our analysis (we did not have codes to separate out subjects by symptomotology) , we performed a visual inspection of each cardiovascular measures captured during testing and plotted them against stand time, pre- to post-flight, and between mission duration. It was found that pulse pressure most clearly differentiated the two mission types. Statistical analysis confirmed that pulse pressure was significantly higher before [45.6; (42.1 to 49.1)] and after [50.7; (46.9 to 54.6)] time on station compared with their most recent shuttle flight [31.6 (27.8 to 35.4), and 32.2 (28.3 to 36.0) respectively] even after correcting differences in age and cumulative number of mission hours. Without knowing the identity of which long duration crewmembers demonstrated visual changes, we were limited to examining whether certain crew regulate components of pulse pressure, systolic and diastolic blood pressure, differently due to microgravity exposure. To that end, we stratified crew into tertiles based on either their pre-flight measure of systolic or diastolic blood pressure. Those crew in the highest tertile for both systolic (lower tertile (n=8; 103-111), middle tertile (n=7; 113-121), and upper tertile (n=5; 125-136) and diastolic blood pressure (lower tertile (n=8; 58-64), middle tertile (n=7; 67-73), and upper tertile (n=5; 75-81) demonstrated less variability in pulse pressure between R+0 and L-10 (Figure 2). Interestingly, those crewmembers with the highest resting systolic blood pressure demonstrated either no change or in some instances an increase in total peripheral resistance, where those in the lower tertiles had lower values of total peripheral resistance compared to pre-flight levels. In this study, it was found that crewmembers in the highest tertile for both systolic and diastolic blood pressure demonstrated less variability in pulse pressure and that the decrease in variability was due in part to lower levels of compliance as indicated by similar or higher levels of total peripheral resistance after compared with before flight levels. Whether there is a relation between blood pressure regulation and total peripheral resistance in crew presenting with negative changes in visual acuity remains unknown." @default.
• W819417883 created "2016-06-24" @default.
• W819417883 creator A5034645772 @default.
• W819417883 creator A5068900179 @default.
• W819417883 creator A5073348121 @default.
• W819417883 date "2011-01-01" @default.
• W819417883 modified "2023-09-23" @default.
• W819417883 title "A Data Mining Project to Identify Cardiovascular Related Factors That May Contribute to Changes in Visual Acuity Within the US Astronaut Corps" @default.
• W819417883 hasPublicationYear "2011" @default.
• W819417883 type Work @default.
• W819417883 sameAs 819417883 @default.
• W819417883 citedByCount "0" @default.
• W819417883 crossrefType "journal-article" @default.
• W819417883 hasAuthorship W819417883A5034645772 @default.
• W819417883 hasAuthorship W819417883A5068900179 @default.
• W819417883 hasAuthorship W819417883A5073348121 @default.
• W819417883 hasConcept C103888896 @default.
• W819417883 hasConcept C112758219 @default.
• W819417883 hasConcept C124952713 @default.
• W819417883 hasConcept C126322002 @default.
• W819417883 hasConcept C127413603 @default.
• W819417883 hasConcept C142362112 @default.
• W819417883 hasConcept C142724271 @default.
• W819417883 hasConcept C146978453 @default.
• W819417883 hasConcept C178802073 @default.
• W819417883 hasConcept C23161992 @default.
• W819417883 hasConcept C2780179797 @default.
• W819417883 hasConcept C52119013 @default.
• W819417883 hasConcept C554144382 @default.
• W819417883 hasConcept C6439246 @default.
• W819417883 hasConcept C71924100 @default.
• W819417883 hasConcept C84393581 @default.
• W819417883 hasConcept C87052748 @default.
• W819417883 hasConcept C99508421 @default.
• W819417883 hasConceptScore W819417883C103888896 @default.
• W819417883 hasConceptScore W819417883C112758219 @default.
• W819417883 hasConceptScore W819417883C124952713 @default.
• W819417883 hasConceptScore W819417883C126322002 @default.
• W819417883 hasConceptScore W819417883C127413603 @default.
• W819417883 hasConceptScore W819417883C142362112 @default.
• W819417883 hasConceptScore W819417883C142724271 @default.
• W819417883 hasConceptScore W819417883C146978453 @default.
• W819417883 hasConceptScore W819417883C178802073 @default.
• W819417883 hasConceptScore W819417883C23161992 @default.
• W819417883 hasConceptScore W819417883C2780179797 @default.
• W819417883 hasConceptScore W819417883C52119013 @default.
• W819417883 hasConceptScore W819417883C554144382 @default.
• W819417883 hasConceptScore W819417883C6439246 @default.
• W819417883 hasConceptScore W819417883C71924100 @default.
• W819417883 hasConceptScore W819417883C84393581 @default.
• W819417883 hasConceptScore W819417883C87052748 @default.
• W819417883 hasConceptScore W819417883C99508421 @default.
• W819417883 hasLocation W8194178831 @default.
• W819417883 hasOpenAccess W819417883 @default.
• W819417883 hasPrimaryLocation W8194178831 @default.
• W819417883 hasRelatedWork W1996872780 @default.
• W819417883 hasRelatedWork W2541523494 @default.
• W819417883 hasRelatedWork W2968869087 @default.
• W819417883 isParatext "false" @default.
• W819417883 isRetracted "false" @default.
• W819417883 magId "819417883" @default.
• W819417883 workType "article" @default.