Matches in SemOpenAlex for { <https://semopenalex.org/work/W820094857> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W820094857 abstract "Purpose: To extend the capabilities of knowledge-based treatment planning beyond simple dose queries by incorporating validated patient outcome models. Methods: From an analytic, relational database of 684 head and neck cancer patients, 372 patients were identified having dose data for both left and right parotid glands as well as baseline and follow-up xerostomia assessments. For each existing patient, knowledge-based treatment planning was simulated for by querying the dose-volume histograms and geometric shape relationships (overlap volume histograms) for all other patients. Dose predictions were captured at normalized volume thresholds (NVT) of 0%, 10%, 20, 30%, 40%, 50%, and 85% and were compared with the actual achieved doses using the Wilcoxon signed-rank test. Next, a logistic regression model was used to predict the maximum severity of xerostomia up to three months following radiotherapy. Baseline xerostomia scores were subtracted from follow-up assessments and were also included in the model. The relative risks from predicted doses and actual doses were computed and compared. Results: The predicted doses for both parotid glands were significantly less than the achieved doses (p < 0.0001), with differences ranging from 830 cGy ± 1270 cGy (0% NVT) to 1673 cGy ± 1197 cGy (30% NVT). The modelled risk of xerostomia ranged from 54% to 64% for achieved doses and from 33% to 51% for the dose predictions. Relative risks varied from 1.24 to 1.87, with maximum relative risk occurring at 85% NVT. Conclusions: Data-driven generation of treatment planning objectives without consideration of the underlying normal tissue complication probability may Result in inferior plans, even if quality metrics indicate otherwise. Inclusion of complication models in knowledge-based treatment planning is necessary in order to close the feedback loop between radiotherapy treatments and patient outcomes. Future work includes advancing and validating complication models in the context of knowledge-based treatment planning. This work is supported by Philips Radiation Oncology Systems." @default.
- W820094857 created "2016-06-24" @default.
- W820094857 creator A5000025215 @default.
- W820094857 creator A5010446644 @default.
- W820094857 creator A5020715128 @default.
- W820094857 creator A5032526919 @default.
- W820094857 creator A5051005965 @default.
- W820094857 creator A5091594941 @default.
- W820094857 date "2015-06-01" @default.
- W820094857 modified "2023-09-26" @default.
- W820094857 title "MO-G-304-01: FEATURED PRESENTATION: Expanding the Knowledge Base for Data-Driven Treatment Planning: Incorporating Patient Outcome Models" @default.
- W820094857 doi "https://doi.org/10.1118/1.4925472" @default.
- W820094857 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26128769" @default.
- W820094857 hasPublicationYear "2015" @default.
- W820094857 type Work @default.
- W820094857 sameAs 820094857 @default.
- W820094857 citedByCount "0" @default.
- W820094857 crossrefType "journal-article" @default.
- W820094857 hasAuthorship W820094857A5000025215 @default.
- W820094857 hasAuthorship W820094857A5010446644 @default.
- W820094857 hasAuthorship W820094857A5020715128 @default.
- W820094857 hasAuthorship W820094857A5032526919 @default.
- W820094857 hasAuthorship W820094857A5051005965 @default.
- W820094857 hasAuthorship W820094857A5091594941 @default.
- W820094857 hasConcept C115961682 @default.
- W820094857 hasConcept C126322002 @default.
- W820094857 hasConcept C126838900 @default.
- W820094857 hasConcept C12868164 @default.
- W820094857 hasConcept C141071460 @default.
- W820094857 hasConcept C151956035 @default.
- W820094857 hasConcept C154945302 @default.
- W820094857 hasConcept C199343813 @default.
- W820094857 hasConcept C201645570 @default.
- W820094857 hasConcept C206041023 @default.
- W820094857 hasConcept C2776530083 @default.
- W820094857 hasConcept C2780395140 @default.
- W820094857 hasConcept C2989005 @default.
- W820094857 hasConcept C3018411727 @default.
- W820094857 hasConcept C41008148 @default.
- W820094857 hasConcept C509974204 @default.
- W820094857 hasConcept C53533937 @default.
- W820094857 hasConcept C71924100 @default.
- W820094857 hasConcept C75088862 @default.
- W820094857 hasConceptScore W820094857C115961682 @default.
- W820094857 hasConceptScore W820094857C126322002 @default.
- W820094857 hasConceptScore W820094857C126838900 @default.
- W820094857 hasConceptScore W820094857C12868164 @default.
- W820094857 hasConceptScore W820094857C141071460 @default.
- W820094857 hasConceptScore W820094857C151956035 @default.
- W820094857 hasConceptScore W820094857C154945302 @default.
- W820094857 hasConceptScore W820094857C199343813 @default.
- W820094857 hasConceptScore W820094857C201645570 @default.
- W820094857 hasConceptScore W820094857C206041023 @default.
- W820094857 hasConceptScore W820094857C2776530083 @default.
- W820094857 hasConceptScore W820094857C2780395140 @default.
- W820094857 hasConceptScore W820094857C2989005 @default.
- W820094857 hasConceptScore W820094857C3018411727 @default.
- W820094857 hasConceptScore W820094857C41008148 @default.
- W820094857 hasConceptScore W820094857C509974204 @default.
- W820094857 hasConceptScore W820094857C53533937 @default.
- W820094857 hasConceptScore W820094857C71924100 @default.
- W820094857 hasConceptScore W820094857C75088862 @default.
- W820094857 hasLocation W8200948571 @default.
- W820094857 hasOpenAccess W820094857 @default.
- W820094857 hasPrimaryLocation W8200948571 @default.
- W820094857 hasRelatedWork W1242259901 @default.
- W820094857 hasRelatedWork W1489345454 @default.
- W820094857 hasRelatedWork W1569228930 @default.
- W820094857 hasRelatedWork W1970469356 @default.
- W820094857 hasRelatedWork W1979641127 @default.
- W820094857 hasRelatedWork W1995373556 @default.
- W820094857 hasRelatedWork W1996796091 @default.
- W820094857 hasRelatedWork W2005960567 @default.
- W820094857 hasRelatedWork W2062950404 @default.
- W820094857 hasRelatedWork W2082140329 @default.
- W820094857 hasRelatedWork W2089896756 @default.
- W820094857 hasRelatedWork W2104783586 @default.
- W820094857 hasRelatedWork W2117402184 @default.
- W820094857 hasRelatedWork W2463537780 @default.
- W820094857 hasRelatedWork W2469058870 @default.
- W820094857 hasRelatedWork W2470705653 @default.
- W820094857 hasRelatedWork W2566478333 @default.
- W820094857 hasRelatedWork W2610528060 @default.
- W820094857 hasRelatedWork W3032555431 @default.
- W820094857 hasRelatedWork W843765107 @default.
- W820094857 isParatext "false" @default.
- W820094857 isRetracted "false" @default.
- W820094857 magId "820094857" @default.
- W820094857 workType "article" @default.