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- W820147986 abstract "This chapter focuses on comparative genomics of Chlamydia species, which are well-known human and animal pathogens that constitute the family Chlamydiaceae. There were 33 chlamydial genome sequences produced by whole-genome shotgun (WGS) sequencing that are publicly available as complete or draft genomes in GenBank. The Chlamydiaceae pangenome was first examined by a BLAST score ratio (BSR) analysis using a single representative of each of the eight sequenced species. The secreted effectors identified in C. trachomatis are more divergent in other species than are the other selected virulence factors. One of the most significant features of the chlamydial plasticity zone (PZ) revealed by comparative analysis is the heterogeneity of the chlamydial cytotoxin (tox) across the Chlamydiaceae. Nevertheless, the tox variation identified here is a prime example of the utility of comparative genomics for identifying novel interspecies genetic variation for further exploration. The chapter focuses further attention on the processes of gene decay and loss that are shaping the Chlamydiaceae. The symptoms of human disease are variable, ranging from no clinical signs at all to severe systemic disease. C. trachomatis is represented by 20 of the 33 genomes currently available, as befitting the most recognizable pathogen of the family Chlamydiaceae, responsible for significant sexually transmitted disease morbidity and infectious blindness worldwide." @default.
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- W820147986 date "2014-04-30" @default.
- W820147986 modified "2023-09-23" @default.
- W820147986 title "Deep and Wide: Comparative Genomics of Chlamydia" @default.
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- W820147986 doi "https://doi.org/10.1128/9781555817329.ch2" @default.
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