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- W82016181 abstract "Topoisomerase I inhibitors have wide applicability in oncology. Reproducible noncumulative toxicity, a known target and potential for combinations with other agents have ensured their clinical role. c has been part of drug regimens for ovarian cancer, small cell lung cancer (SCLC), and cancer of the uterine cervix; it has also been used as a radiosensitizer in non-small cell lung cancer (NSCLC). Irinotecan was the second drug with activity in colon cancer after failure of many drug classes to build on the long-established 5-fluorouracil-based regimens. Irinotecan also has a prominent role in the treatment of a number of other gastrointestinal, pulmonary, gynecological, and central nervous system cancers. Reasons for their individual selectivity are not readily apparent, with pharmacology likely to account for differences in toxicity and efficacy among this family of drugs. This overview also provides a glimpse at other Top1 inhibitors under development. Advances in our understanding of Top1 action covered elsewhere in this volume, and reasons for selectivity and resistance will undoubtedly extend the clinical applications of these drugs." @default.
- W82016181 created "2016-06-24" @default.
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- W82016181 date "2011-08-26" @default.
- W82016181 modified "2023-09-27" @default.
- W82016181 title "Topoisomerase I Inhibitors: Current Use and Prospects" @default.
- W82016181 cites W139142104 @default.
- W82016181 cites W146134068 @default.
- W82016181 cites W1498349189 @default.
- W82016181 cites W1512945076 @default.
- W82016181 cites W1525737532 @default.
- W82016181 cites W1567205022 @default.
- W82016181 cites W1832060645 @default.
- W82016181 cites W1898063915 @default.
- W82016181 cites W1913802169 @default.
- W82016181 cites W1920900131 @default.
- W82016181 cites W1932169383 @default.
- W82016181 cites W1960327677 @default.
- W82016181 cites W1970438208 @default.
- W82016181 cites W1971263088 @default.
- W82016181 cites W1971687526 @default.
- W82016181 cites W1975693150 @default.
- W82016181 cites W1982457488 @default.
- W82016181 cites W1993088391 @default.
- W82016181 cites W1995727180 @default.
- W82016181 cites W1997712655 @default.
- W82016181 cites W2002875079 @default.
- W82016181 cites W2006824814 @default.
- W82016181 cites W2007246460 @default.
- W82016181 cites W2008745407 @default.
- W82016181 cites W2012792853 @default.
- W82016181 cites W2012797500 @default.
- W82016181 cites W2013617883 @default.
- W82016181 cites W2017291594 @default.
- W82016181 cites W2021960861 @default.
- W82016181 cites W2022994921 @default.
- W82016181 cites W2024114545 @default.
- W82016181 cites W2025416665 @default.
- W82016181 cites W2030786793 @default.
- W82016181 cites W2030953740 @default.
- W82016181 cites W2037823066 @default.
- W82016181 cites W2038551606 @default.
- W82016181 cites W2043509473 @default.
- W82016181 cites W2043728323 @default.
- W82016181 cites W2050174492 @default.
- W82016181 cites W2054458932 @default.
- W82016181 cites W2055159778 @default.
- W82016181 cites W2059184955 @default.
- W82016181 cites W2064214863 @default.
- W82016181 cites W2065412623 @default.
- W82016181 cites W2066407881 @default.
- W82016181 cites W2073683299 @default.
- W82016181 cites W2075944900 @default.
- W82016181 cites W2080953759 @default.
- W82016181 cites W2089458883 @default.
- W82016181 cites W2089937596 @default.
- W82016181 cites W2090672510 @default.
- W82016181 cites W2092998745 @default.
- W82016181 cites W2093783077 @default.
- W82016181 cites W2094841344 @default.
- W82016181 cites W2094943043 @default.
- W82016181 cites W2095201384 @default.
- W82016181 cites W2096096300 @default.
- W82016181 cites W2096136751 @default.
- W82016181 cites W2096139576 @default.
- W82016181 cites W2097074370 @default.
- W82016181 cites W2099808007 @default.
- W82016181 cites W2102601598 @default.
- W82016181 cites W2103945023 @default.
- W82016181 cites W2104709039 @default.
- W82016181 cites W2105100844 @default.
- W82016181 cites W2105431194 @default.
- W82016181 cites W2105878476 @default.
- W82016181 cites W2106845199 @default.
- W82016181 cites W2107997901 @default.
- W82016181 cites W2108018389 @default.
- W82016181 cites W2108293816 @default.
- W82016181 cites W2114098415 @default.
- W82016181 cites W2114133306 @default.
- W82016181 cites W2118508302 @default.
- W82016181 cites W2118629831 @default.
- W82016181 cites W2118714282 @default.
- W82016181 cites W2119071284 @default.
- W82016181 cites W2119100187 @default.
- W82016181 cites W2120490763 @default.
- W82016181 cites W2121113526 @default.
- W82016181 cites W2126254858 @default.
- W82016181 cites W2127191258 @default.
- W82016181 cites W2127745545 @default.
- W82016181 cites W2128403792 @default.
- W82016181 cites W2128447158 @default.
- W82016181 cites W2132310090 @default.
- W82016181 cites W2132545630 @default.