Matches in SemOpenAlex for { <https://semopenalex.org/work/W8201858> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W8201858 endingPage "303" @default.
- W8201858 startingPage "298" @default.
- W8201858 abstract "The present work was aimed to compare levofloxacin pulmonary disposition after systemic or inhalatory delivery and to evaluate the influence of respiratory pattern on lung distribution. An experimental model of the isolated lung of the rat was used. Twenty-four Wistar rats were distributed in four groups receiving levofloxacin under different experimental conditions including systemic or pulmonary delivery and higher or lower respiratory frequency with lower or higher tidal volume, respectively. Levofloxacin (500 microg) was administered as a bolus injection or by inhalation. Lung tissue samples as well as efferent and broncoalveolar fluid were collected. Quantification of levofloxacin levels in all samples was performed by a high-performance liquid chromatography (HPLC) technique. Pulmonary distribution coefficient of levofloxacin after systemic delivery showed mean values of 1.19+/-0.13 and 3.34+/-0.61 ml/g for each respiratory pattern assayed. The partition coefficients estimated from simultaneous drug level in lung tissue and efferent fluid (EF) are in agreement with the above values. Comparison of systemic and pulmonary administration reveals statistical significant differences between partition coefficients showing much higher values for the latter route (8.01+/-5.53 versus 2.86+/-1.35). In conclusion, inhalation compared to systemic administration improves levofloxacin access to the lung tissue; the experimental approach used here to assess the pulmonary drug disposition may be a useful model for biopharmaceutical studies of inhaled therapeutics." @default.
- W8201858 created "2016-06-24" @default.
- W8201858 creator A5003135549 @default.
- W8201858 creator A5052344596 @default.
- W8201858 creator A5054063781 @default.
- W8201858 date "2008-04-01" @default.
- W8201858 modified "2023-10-14" @default.
- W8201858 title "Pulmonary versus systemic delivery of levofloxacin" @default.
- W8201858 cites W2019988983 @default.
- W8201858 cites W2036563403 @default.
- W8201858 cites W2055324007 @default.
- W8201858 cites W2056096386 @default.
- W8201858 cites W2059545303 @default.
- W8201858 cites W2094215354 @default.
- W8201858 cites W2097897268 @default.
- W8201858 cites W2107697524 @default.
- W8201858 cites W2112427833 @default.
- W8201858 cites W2116879668 @default.
- W8201858 cites W2128104724 @default.
- W8201858 cites W2168418918 @default.
- W8201858 cites W2169922352 @default.
- W8201858 cites W4247128285 @default.
- W8201858 cites W82875543 @default.
- W8201858 doi "https://doi.org/10.1016/j.pupt.2007.07.003" @default.
- W8201858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17869149" @default.
- W8201858 hasPublicationYear "2008" @default.
- W8201858 type Work @default.
- W8201858 sameAs 8201858 @default.
- W8201858 citedByCount "18" @default.
- W8201858 countsByYear W82018582012 @default.
- W8201858 countsByYear W82018582014 @default.
- W8201858 countsByYear W82018582015 @default.
- W8201858 countsByYear W82018582016 @default.
- W8201858 countsByYear W82018582018 @default.
- W8201858 countsByYear W82018582021 @default.
- W8201858 countsByYear W82018582022 @default.
- W8201858 countsByYear W82018582023 @default.
- W8201858 crossrefType "journal-article" @default.
- W8201858 hasAuthorship W8201858A5003135549 @default.
- W8201858 hasAuthorship W8201858A5052344596 @default.
- W8201858 hasAuthorship W8201858A5054063781 @default.
- W8201858 hasConcept C126322002 @default.
- W8201858 hasConcept C185592680 @default.
- W8201858 hasConcept C2776512019 @default.
- W8201858 hasConcept C2776954882 @default.
- W8201858 hasConcept C2777714996 @default.
- W8201858 hasConcept C2779263132 @default.
- W8201858 hasConcept C2781276175 @default.
- W8201858 hasConcept C42219234 @default.
- W8201858 hasConcept C501593827 @default.
- W8201858 hasConcept C534529494 @default.
- W8201858 hasConcept C55493867 @default.
- W8201858 hasConcept C71924100 @default.
- W8201858 hasConcept C98274493 @default.
- W8201858 hasConceptScore W8201858C126322002 @default.
- W8201858 hasConceptScore W8201858C185592680 @default.
- W8201858 hasConceptScore W8201858C2776512019 @default.
- W8201858 hasConceptScore W8201858C2776954882 @default.
- W8201858 hasConceptScore W8201858C2777714996 @default.
- W8201858 hasConceptScore W8201858C2779263132 @default.
- W8201858 hasConceptScore W8201858C2781276175 @default.
- W8201858 hasConceptScore W8201858C42219234 @default.
- W8201858 hasConceptScore W8201858C501593827 @default.
- W8201858 hasConceptScore W8201858C534529494 @default.
- W8201858 hasConceptScore W8201858C55493867 @default.
- W8201858 hasConceptScore W8201858C71924100 @default.
- W8201858 hasConceptScore W8201858C98274493 @default.
- W8201858 hasIssue "2" @default.
- W8201858 hasLocation W82018581 @default.
- W8201858 hasLocation W82018582 @default.
- W8201858 hasOpenAccess W8201858 @default.
- W8201858 hasPrimaryLocation W82018581 @default.
- W8201858 hasRelatedWork W1980038448 @default.
- W8201858 hasRelatedWork W2074440122 @default.
- W8201858 hasRelatedWork W2350327883 @default.
- W8201858 hasRelatedWork W2379210937 @default.
- W8201858 hasRelatedWork W2387067130 @default.
- W8201858 hasRelatedWork W2387493645 @default.
- W8201858 hasRelatedWork W2390416040 @default.
- W8201858 hasRelatedWork W2469966616 @default.
- W8201858 hasRelatedWork W3156458452 @default.
- W8201858 hasRelatedWork W3168415965 @default.
- W8201858 hasVolume "21" @default.
- W8201858 isParatext "false" @default.
- W8201858 isRetracted "false" @default.
- W8201858 magId "8201858" @default.
- W8201858 workType "article" @default.