FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W820278315> ?p ?o ?g. }

• W820278315 abstract "Yersinia pestis, the causative agent of plague, is estimated to have claimed the lives of 30-50% of the European population in five years. Although it can now be controlled through antibiotics, there are still lurking dangers of outbreaks from biowarfare and bioterrorism; therefore, ongoing research to further our understanding of its strong virulence factors is necessary for development of new vaccines. Many Gram-negative bacteria, including Y. pseudotuberculosis, the evolutionary ancestor of Y. pestis, produce a hexa-acylated lipid A/LPS which can strongly trigger innate immune responses via activation of Toll-like receptor 4 (TLR4)-MD2. In contrast, Y. pestis grown at 37oC generates a tetra-acylated lipid A/LPS that poorly induces TLR4-mediated immune activation. We have reported that expression of E. coli lpxL in Y. pestis, which lacks a homologue of this gene, forces the biosynthesis of a hexaacylated LPS, and that this single modification dramatically reduces virulence in wild type mice, but not in mice lacking a functional TLR4. This emphasizes that avoiding activation of innate immunity is important for Y. pestis virulence. It also provides a model in which survival is strongly dependent on innate immune defenses, presenting a unique opportunity for evaluating the relative importance of innate immunity in protection against bacterial infection. TLR signaling is critical for the sensing of pathogens, and one implication of TLR4 engagement is the induction of the pro-forms of the potent inflammatory cytokines IL-1β and IL-18. Therefore Y. pestis is able to suppress production of these which are generated through caspase-1-activating nucleotide-binding domain and leucine-rich repeat (NLR)-containing inflammasomes. For my thesis, I sought to elucidate the role of NLRs and IL-18/IL-1β during bubonic and pneumonic vii" @default.
• W820278315 created "2016-06-24" @default.
• W820278315 creator A5045856086 @default.
• W820278315 date "2013-01-01" @default.
• W820278315 modified "2023-09-23" @default.
• W820278315 title "Inflammasomes and the Innate Immune Response Against Yersinia Pestis: A Dissertation" @default.
• W820278315 cites W124870403 @default.
• W820278315 cites W1497860205 @default.
• W820278315 cites W1512784038 @default.
• W820278315 cites W1512982701 @default.
• W820278315 cites W1519633296 @default.
• W820278315 cites W1529674879 @default.
• W820278315 cites W1534658432 @default.
• W820278315 cites W1547524864 @default.
• W820278315 cites W1577331826 @default.
• W820278315 cites W1587650589 @default.
• W820278315 cites W1604936501 @default.
• W820278315 cites W1671630222 @default.
• W820278315 cites W1714542354 @default.
• W820278315 cites W1756957577 @default.
• W820278315 cites W1790604550 @default.
• W820278315 cites W1825734539 @default.
• W820278315 cites W1845637086 @default.
• W820278315 cites W1855676723 @default.
• W820278315 cites W1891826181 @default.
• W820278315 cites W1891980138 @default.
• W820278315 cites W1901875036 @default.
• W820278315 cites W1946177303 @default.
• W820278315 cites W1947904991 @default.
• W820278315 cites W1963492948 @default.
• W820278315 cites W1965116404 @default.
• W820278315 cites W1965315844 @default.
• W820278315 cites W1965970815 @default.
• W820278315 cites W1966625479 @default.
• W820278315 cites W1966772446 @default.
• W820278315 cites W1966914633 @default.
• W820278315 cites W1967046222 @default.
• W820278315 cites W1967725137 @default.
• W820278315 cites W1968178474 @default.
• W820278315 cites W1969072247 @default.
• W820278315 cites W1969501356 @default.
• W820278315 cites W1969603232 @default.
• W820278315 cites W1972169896 @default.
• W820278315 cites W1972483153 @default.
• W820278315 cites W1973437785 @default.
• W820278315 cites W1973528297 @default.
• W820278315 cites W1974687506 @default.
• W820278315 cites W1974744480 @default.
• W820278315 cites W1974760528 @default.
• W820278315 cites W1975014158 @default.
• W820278315 cites W1975064863 @default.
• W820278315 cites W1977100459 @default.
• W820278315 cites W1977416546 @default.
• W820278315 cites W1983053357 @default.
• W820278315 cites W1985538633 @default.
• W820278315 cites W1987535382 @default.
• W820278315 cites W1987609001 @default.
• W820278315 cites W1988197452 @default.
• W820278315 cites W1988652189 @default.
• W820278315 cites W1989249407 @default.
• W820278315 cites W1989656760 @default.
• W820278315 cites W1990720057 @default.
• W820278315 cites W1991236592 @default.
• W820278315 cites W1991909065 @default.
• W820278315 cites W1992014522 @default.
• W820278315 cites W1992359197 @default.
• W820278315 cites W1993728991 @default.
• W820278315 cites W1993832002 @default.
• W820278315 cites W1995484660 @default.
• W820278315 cites W1996264333 @default.
• W820278315 cites W1996671942 @default.
• W820278315 cites W1999286245 @default.
• W820278315 cites W1999453285 @default.
• W820278315 cites W2001366460 @default.
• W820278315 cites W2003459196 @default.
• W820278315 cites W2005360556 @default.
• W820278315 cites W2005473844 @default.
• W820278315 cites W2006049439 @default.
• W820278315 cites W2006130551 @default.
• W820278315 cites W2007747853 @default.
• W820278315 cites W2008472051 @default.
• W820278315 cites W2009523990 @default.
• W820278315 cites W2009800174 @default.
• W820278315 cites W2010519412 @default.
• W820278315 cites W2012270515 @default.
• W820278315 cites W2012443484 @default.
• W820278315 cites W2012576192 @default.
• W820278315 cites W2012737807 @default.
• W820278315 cites W2013397493 @default.
• W820278315 cites W2014011959 @default.
• W820278315 cites W2014477644 @default.
• W820278315 cites W2015263036 @default.
• W820278315 cites W2015316514 @default.
• W820278315 cites W2015449243 @default.
• W820278315 cites W2016503643 @default.
• W820278315 cites W2017515700 @default.
• W820278315 cites W2018563185 @default.
• W820278315 cites W2019737761 @default.
• W820278315 cites W2020683003 @default.
• W820278315 cites W2021646146 @default.

• next