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- W820717085 endingPage "1079" @default.
- W820717085 startingPage "1065" @default.
- W820717085 abstract "Intraperitoneal (IP) chemotherapy confers significant survival benefits in cancer patients. However, several problems, including local toxicity and ineffectiveness against bulky tumors, have prohibited it from becoming a standard-of-care. We have developed drug-loaded, tumor-penetrating microparticles (TPM) to address these problems. TPM comprises two components and uses the versatile PLGA or poly(lacticco-glycolic acid) copolymer to provide tumor-selective adherence and pharmacodynamically optimized fractionated dosing to achieve the desired tumor priming (which promotes particle penetration into tumors) plus immediate and sustained antitumor activity. Preclinical studies show that TPM is less toxic and more effective against several IP metastatic tumors with different characteristics (fast vs. slow growing, porous vs. densely packed structures, wide-spread vs. solitary tumors, early vs. late stage, with or without peritoneal carcinomatosis or ascites), compared to the intravenous paclitaxel/Cremophor micellar solution that has been used off-label in previous IP studies. TPM further requires less frequent dosing. These encouraging preclinical results have motivated the follow-up clinical development of TPM. We are working with National Institutes of Health on the IND-enabling studies." @default.
- W820717085 created "2016-06-24" @default.
- W820717085 creator A5077645346 @default.
- W820717085 creator A5080936191 @default.
- W820717085 creator A5085031128 @default.
- W820717085 date "2015-06-19" @default.
- W820717085 modified "2023-09-26" @default.
- W820717085 title "Versatility of Particulate Carriers: Development of Pharmacodynamically Optimized Drug-Loaded Microparticles for Treatment of Peritoneal Cancer" @default.
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- W820717085 doi "https://doi.org/10.1208/s12248-015-9785-x" @default.
- W820717085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4540721" @default.
- W820717085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26089090" @default.
- W820717085 hasPublicationYear "2015" @default.