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- W821208251 abstract "A substantial amount of evidence has implicated defects in energy metabolism in Alzheimer’s disease (AD) (Beal, 1992). Several studies have utilized positron emission tomography (PET) to show that a decrease in glucose metabolism occurs in parietal and temporal cortex early in the course of AD (Duara et al., 1986; Haxby et al., 1986). There is high metabolic rate for oxygen relative to glucose consistent with impaired glucose utilization. Furthermore, a recent study has demonstrated an increase in organic phosphate relative to phosphocreatine using phosphorous nuclear magnetic resonance spectroscopy (Smith et al., 1995).KeywordsCytochrome OxidaseExcitatory Amino Acid ReceptorCytochrome Oxidase ActivityStriatal LesionImpaired Glucose UtilizationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W821208251 date "1997-01-01" @default.
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- W821208251 title "Therapeutic Strategies in Alzheimer’s Disease" @default.
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- W821208251 doi "https://doi.org/10.1007/978-1-4612-4116-4_49" @default.
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