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- W821465240 abstract "Ethyl cellulose (EC) is one of the most important coating materials for controlled releaseformulations. To achieve the desirable drug release, the physical properties of EC filmsincorporated with various functional additives need to be fully understood. Therefore, theaim of this project is to characterize the physical properties of EC films incorporated withvarious plasticizers and pore forming agents, hence to understand the drug releasemechanisms in relation to the physical characteristics of EC films. The thermal propertiesof EC powder and EC films were initially characterized by means of thermogravimetricanalysis (TGA), differential scanning calorimetry (DSC), modulated temperature DSC(MTDSC) and dynamic mechanical analysis (DMA). Subsequently, oleic acid (OA), dibutylsebacate (DBS) and medium chain triglycerides (MCT) were incorporated as plasticizerswhile hydroxypropyl methylcellulose (HPMC) was utilized as the pore forming agent. Thethermal, thermo-mechanical and phase distribution of EC films incorporated withplasticizers and/or HPMC were investigated using MTDSC, DMA and localized thermalanalysis (LTA). These results were compared with the thermal properties and scanningelectron microscopy (SEM) images of the free films after immersion into water, pH 1.2 and6.8 buffers. Dissolution of metoprolol succinate and paracetamol from SureSpheres®pellets coated by these films were then carried out. OA and DBS were more efficient thanMCT for EC films. OA and DBS showed good compatibility with EC, whereas at 20%plasticizer level and beyond, EC/MCT films presented two EC phases with 8% and 24%MCT respectively. The addition of HPMC to EC films did not show a significant effect ontheir thermal properties. However, the phase distribution of HPMC domains was affectedby the HPMC levels. After immersion into the release media, HPMC generated water filledpores quickly in the first two hours. The shape and sizes of these pores were correspondingto the phase distribution of HPMC domains. The release from these films appeared tofollow zero-order kinetics, except for metoprolol succinate from pellets coated byEC/plasticizer/HPMC films, which followed the Higuchi model. It is suggested that thedissolution rate of HPMC, film properties and solubility of the model drugs is the ratedeterminingstep." @default.
- W821465240 created "2016-06-24" @default.
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- W821465240 date "2012-03-01" @default.
- W821465240 modified "2023-09-26" @default.
- W821465240 title "A thermal/thermo-mechanical and imaging study of component distribution and interaction in pharmaceutical film coats" @default.
- W821465240 hasPublicationYear "2012" @default.
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