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- W821622317 abstract "Objectives : Asthma is characterized by acute and chronic airway inflammation, and the severity of the airway hyperreactivity correlates with the degree of inflammation. The goal of this study was to investigate the effects of the Rdix Platicodi(RP) used to treat allergic asthma, on a well-characterized mouse model of allergic asthma. Methods: Mice sensitized intraperitoneally and challenged intratracheally with conalbumin were treated with RP 24hr after the first intratracheal challenge. The effects of RP on allergic airway hyperreactivity, inflammation, antigen-specific antibody production, cytokine profiles were evaluated. Results : RP treatment virtually eliminated airway hyperreactivity and markedly reduced the total number of cells and the percent eosinophils in bronchoalveolar lavage fluids compared with the control group. RP treatment decreased antigen-specific IgE, IgG2a, IL-4, IL-5, and IL-13 levels, but synthesis increased as compared with control group. Conclusions : From the above results, RP exhibits anti-airway hyperresponsiveness, anti-airway inflammation, and immunoregulatory effects on Thl/Th2 response, which may be useful for treatment of allergic asthma." @default.
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- W821622317 date "2004-01-01" @default.
- W821622317 modified "2023-09-27" @default.
- W821622317 title "Studies on the allergy asthma effect of Radix Platicodi" @default.
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