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• W82177955 abstract "The aim of this study was to evaluate the vehicle effect on in vitro diffusion of Diphenhydraminehydrochloride (DPH) from new five topical formulations: microemulsion (A), microemulsion+silica (B), Na Alginateemulgel (C), Carbopol cream (D) and hydroxyethylcellulose gel (E).Furthermore, the skin irritation potential and theformulation effect on skin reaction induced by histamine were investigated in vivo . The commercial cream of DPH (Allergan ® ) was used as reference formulation.The diffusion rate values showed the rank order E > A > B > C > D > Control, and all prepared formulations are able to improve the diffusion of drug compared with commercial cream; among the tested formulations, the hydroxyethylcellulose gel and microemulsions appear to be the most efficient vehicles in promoting the release of DPH.After in vivo application, the formulations do not produce skin irritation and determine a reduction of the response induced by histamine suggesting that their potential use as alternative topical dosage forms for effective local antihistaminic therapy." @default.
• W82177955 created "2016-06-24" @default.
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• W82177955 date "2010-01-01" @default.
• W82177955 modified "2023-10-01" @default.
• W82177955 title "Development of new topical formulations ofdiphenhydramine hydrochloride: in vitro diffusion and in vivo preliminary studies" @default.
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