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- W82184047 endingPage "2964" @default.
- W82184047 startingPage "2951" @default.
- W82184047 abstract "Abstract Infection with the human immunodeficiency virus (HIV) is associated with a progressive decrease in CD4 T-cell number and a consequent impairment in host immune defenses. Analysis of T cells from patients infected with HIV, or of T cells infected in vitro with HIV, demonstrates a significant fraction of both infected and uninfected cells dying by apoptosis. The many mechanisms that contribute to HIV-associated lymphocyte apoptosis include chronic immunologic activation; gp120/160 ligation of the CD4 receptor; enhanced production of cytotoxic ligands or viral proteins by monocytes, macrophages, B cells, and CD8 T cells from HIV-infected patients that kill uninfected CD4 T cells; and direct infection of target cells by HIV, resulting in apoptosis. Although HIV infection results in T-cell apoptosis, under some circumstances HIV infection of resting T cells or macrophages does not result in apoptosis; this may be a critical step in the development of viral reservoirs. Recent therapies for HIV effectively reduce lymphoid and peripheral T-cell apoptosis, reduce viral replication, and enhance cellular immune competence; however, they do not alter viral reservoirs. Further understanding the regulation of apoptosis in HIV disease is required to develop novel immune-based therapies aimed at modifying HIV-induced apoptosis to the benefit of patients infected with HIV." @default.
- W82184047 created "2016-06-24" @default.
- W82184047 creator A5016102389 @default.
- W82184047 creator A5044416033 @default.
- W82184047 creator A5058306758 @default.
- W82184047 creator A5077722019 @default.
- W82184047 date "2000-11-01" @default.
- W82184047 modified "2023-09-30" @default.
- W82184047 title "Mechanisms of HIV-associated lymphocyte apoptosis" @default.
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