Matches in SemOpenAlex for { <https://semopenalex.org/work/W82202312> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W82202312 endingPage "429" @default.
- W82202312 startingPage "419" @default.
- W82202312 abstract "Toxication of xenobiotics by intracellular activation to potent alkylating or arylating agents has been observed in several classes of drugs. For N-acetamidophenols, transformation into reactive intermediates by a cytochrome P-450 mixed function oxidase leading, hypothetically via N-hydroxy derivatives, to the assumed ultimate toxic compound N-acetylbenzoquinonimine has been proposed by Nery 1 and extended by Gillette and Mitchell 2, 3. In this laboratory the biotransformation and toxicity of 4-dimethylaminophenol (DMAP), an antidote used in cyanide poisoning4–6,has been studied in vivo, in isolated cells, and in vitro. Since toxicity of N-acetamidophenols aminophenols is manifested by damage to liver7 and/or kidney8, 9, we extended investigations on the biotransformation of DMAP to the alterations of cellular intermediary metabolism in isolated perfused rat liver and kidney. This communication summarizes some of our findings on the mechanism of DMAP-toxicity which could be similar to other 4-aminophenols capable to form a p-quinonimine structure." @default.
- W82202312 created "2016-06-24" @default.
- W82202312 creator A5025546929 @default.
- W82202312 creator A5043494714 @default.
- W82202312 creator A5057422891 @default.
- W82202312 creator A5070174544 @default.
- W82202312 date "1982-01-01" @default.
- W82202312 modified "2023-09-26" @default.
- W82202312 title "Organ Toxicity and Metabolic Pathway of 4-Dimethylaminophenol" @default.
- W82202312 cites W122529857 @default.
- W82202312 cites W1880556660 @default.
- W82202312 cites W1971084433 @default.
- W82202312 cites W1971954053 @default.
- W82202312 cites W1975966390 @default.
- W82202312 cites W2015710607 @default.
- W82202312 cites W2020014184 @default.
- W82202312 cites W2040866316 @default.
- W82202312 cites W2050068664 @default.
- W82202312 cites W2051980129 @default.
- W82202312 cites W2065234099 @default.
- W82202312 cites W2065909576 @default.
- W82202312 cites W2089636404 @default.
- W82202312 cites W2093319217 @default.
- W82202312 cites W2095214547 @default.
- W82202312 cites W2131331691 @default.
- W82202312 cites W2135409766 @default.
- W82202312 cites W2229902915 @default.
- W82202312 cites W36230439 @default.
- W82202312 doi "https://doi.org/10.1007/978-1-4757-0674-1_30" @default.
- W82202312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7344472" @default.
- W82202312 hasPublicationYear "1982" @default.
- W82202312 type Work @default.
- W82202312 sameAs 82202312 @default.
- W82202312 citedByCount "1" @default.
- W82202312 crossrefType "book-chapter" @default.
- W82202312 hasAuthorship W82202312A5025546929 @default.
- W82202312 hasAuthorship W82202312A5043494714 @default.
- W82202312 hasAuthorship W82202312A5057422891 @default.
- W82202312 hasAuthorship W82202312A5070174544 @default.
- W82202312 hasConcept C150903083 @default.
- W82202312 hasConcept C178790620 @default.
- W82202312 hasConcept C181199279 @default.
- W82202312 hasConcept C185592680 @default.
- W82202312 hasConcept C207001950 @default.
- W82202312 hasConcept C2778455166 @default.
- W82202312 hasConcept C2779365888 @default.
- W82202312 hasConcept C27881333 @default.
- W82202312 hasConcept C29730261 @default.
- W82202312 hasConcept C526171541 @default.
- W82202312 hasConcept C55493867 @default.
- W82202312 hasConcept C62231903 @default.
- W82202312 hasConcept C86803240 @default.
- W82202312 hasConcept C98274493 @default.
- W82202312 hasConceptScore W82202312C150903083 @default.
- W82202312 hasConceptScore W82202312C178790620 @default.
- W82202312 hasConceptScore W82202312C181199279 @default.
- W82202312 hasConceptScore W82202312C185592680 @default.
- W82202312 hasConceptScore W82202312C207001950 @default.
- W82202312 hasConceptScore W82202312C2778455166 @default.
- W82202312 hasConceptScore W82202312C2779365888 @default.
- W82202312 hasConceptScore W82202312C27881333 @default.
- W82202312 hasConceptScore W82202312C29730261 @default.
- W82202312 hasConceptScore W82202312C526171541 @default.
- W82202312 hasConceptScore W82202312C55493867 @default.
- W82202312 hasConceptScore W82202312C62231903 @default.
- W82202312 hasConceptScore W82202312C86803240 @default.
- W82202312 hasConceptScore W82202312C98274493 @default.
- W82202312 hasLocation W822023121 @default.
- W82202312 hasLocation W822023122 @default.
- W82202312 hasOpenAccess W82202312 @default.
- W82202312 hasPrimaryLocation W822023121 @default.
- W82202312 hasRelatedWork W1531940184 @default.
- W82202312 hasRelatedWork W1603625312 @default.
- W82202312 hasRelatedWork W1608447397 @default.
- W82202312 hasRelatedWork W169524635 @default.
- W82202312 hasRelatedWork W1983041307 @default.
- W82202312 hasRelatedWork W2009786324 @default.
- W82202312 hasRelatedWork W2074076166 @default.
- W82202312 hasRelatedWork W2079763637 @default.
- W82202312 hasRelatedWork W2312905919 @default.
- W82202312 hasRelatedWork W2890097984 @default.
- W82202312 isParatext "false" @default.
- W82202312 isRetracted "false" @default.
- W82202312 magId "82202312" @default.
- W82202312 workType "book-chapter" @default.