Matches in SemOpenAlex for { <https://semopenalex.org/work/W82281364> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W82281364 endingPage "7" @default.
- W82281364 startingPage "II294" @default.
- W82281364 abstract "The effect of pretransplant sensitization on outcome after cardiac transplant has been controversial. Sensitization, defined as a positive panel-reactive antibody (PRA) screen in patients awaiting transplant, represents circulating antibodies to a random panel of donor lymphocytes (usually T lymphocytes). The significance of pretransplant circulating antibodies to B lymphocytes has not been reported, and many centers disregard its use.We retrospectively reviewed the pretransplant PRA screens for 311 patients who underwent cardiac transplant at our institution. The PRA screen was performed by use of the lymphocytotoxic technique treated with dithiothreitol to remove IgM autoantibodies. Patients with PRA > or = 11% against T or B lymphocytes had significantly lower 3-year survival (T lymphocytes, 39%; B lymphocytes, 56%) than those patients with PRA = 0% and PRA = 1% to 10% (T lymphocytes, 76% and 78%; B lymphocytes, 78% and 74%, respectively) (P < .001). For this high-risk group, the rejection episode tended to occur earlier than in those patients with PRA = 0% and PRA = 1% to 10% (T lymphocytes, 2.3 versus 4.0 and 3.8 months; B lymphocytes, 2.1 versus 4.1 and 3.4 months, respectively), and there were more clinically severe rejections that required OKT3 therapy.Cardiac transplant patients with pretransplant T- and/or B-lymphocyte PRA > or = 11% despite negative donor-specific crossmatch at the time of transplant appear to have earlier and more severe rejection with significantly lower survival after transplant surgery. Modification of immunosuppression in these high-risk patients may be warranted." @default.
- W82281364 created "2016-06-24" @default.
- W82281364 creator A5004300814 @default.
- W82281364 creator A5012268527 @default.
- W82281364 creator A5026395409 @default.
- W82281364 creator A5031568129 @default.
- W82281364 creator A5035769573 @default.
- W82281364 creator A5041687243 @default.
- W82281364 creator A5046477718 @default.
- W82281364 creator A5064888545 @default.
- W82281364 creator A5069083851 @default.
- W82281364 creator A5071437084 @default.
- W82281364 date "1996-11-01" @default.
- W82281364 modified "2023-09-27" @default.
- W82281364 title "Pretransplant panel reactive-antibody screens. Are they truly a marker for poor outcome after cardiac transplantation?" @default.
- W82281364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8901763" @default.
- W82281364 hasPublicationYear "1996" @default.
- W82281364 type Work @default.
- W82281364 sameAs 82281364 @default.
- W82281364 citedByCount "19" @default.
- W82281364 countsByYear W822813642012 @default.
- W82281364 countsByYear W822813642013 @default.
- W82281364 countsByYear W822813642014 @default.
- W82281364 countsByYear W822813642016 @default.
- W82281364 countsByYear W822813642018 @default.
- W82281364 countsByYear W822813642019 @default.
- W82281364 countsByYear W822813642021 @default.
- W82281364 crossrefType "journal-article" @default.
- W82281364 hasAuthorship W82281364A5004300814 @default.
- W82281364 hasAuthorship W82281364A5012268527 @default.
- W82281364 hasAuthorship W82281364A5026395409 @default.
- W82281364 hasAuthorship W82281364A5031568129 @default.
- W82281364 hasAuthorship W82281364A5035769573 @default.
- W82281364 hasAuthorship W82281364A5041687243 @default.
- W82281364 hasAuthorship W82281364A5046477718 @default.
- W82281364 hasAuthorship W82281364A5064888545 @default.
- W82281364 hasAuthorship W82281364A5069083851 @default.
- W82281364 hasAuthorship W82281364A5071437084 @default.
- W82281364 hasConcept C126322002 @default.
- W82281364 hasConcept C159654299 @default.
- W82281364 hasConcept C163764329 @default.
- W82281364 hasConcept C203014093 @default.
- W82281364 hasConcept C2776217527 @default.
- W82281364 hasConcept C2777761686 @default.
- W82281364 hasConcept C2778849806 @default.
- W82281364 hasConcept C2780252810 @default.
- W82281364 hasConcept C2780303639 @default.
- W82281364 hasConcept C2911091166 @default.
- W82281364 hasConcept C64518967 @default.
- W82281364 hasConcept C71924100 @default.
- W82281364 hasConcept C90924648 @default.
- W82281364 hasConceptScore W82281364C126322002 @default.
- W82281364 hasConceptScore W82281364C159654299 @default.
- W82281364 hasConceptScore W82281364C163764329 @default.
- W82281364 hasConceptScore W82281364C203014093 @default.
- W82281364 hasConceptScore W82281364C2776217527 @default.
- W82281364 hasConceptScore W82281364C2777761686 @default.
- W82281364 hasConceptScore W82281364C2778849806 @default.
- W82281364 hasConceptScore W82281364C2780252810 @default.
- W82281364 hasConceptScore W82281364C2780303639 @default.
- W82281364 hasConceptScore W82281364C2911091166 @default.
- W82281364 hasConceptScore W82281364C64518967 @default.
- W82281364 hasConceptScore W82281364C71924100 @default.
- W82281364 hasConceptScore W82281364C90924648 @default.
- W82281364 hasIssue "9 Suppl" @default.
- W82281364 hasLocation W822813641 @default.
- W82281364 hasOpenAccess W82281364 @default.
- W82281364 hasPrimaryLocation W822813641 @default.
- W82281364 hasRelatedWork W11688062 @default.
- W82281364 hasRelatedWork W2031905091 @default.
- W82281364 hasRelatedWork W2040879941 @default.
- W82281364 hasRelatedWork W2043263636 @default.
- W82281364 hasRelatedWork W2048148705 @default.
- W82281364 hasRelatedWork W2093828525 @default.
- W82281364 hasRelatedWork W2150606659 @default.
- W82281364 hasRelatedWork W2162228078 @default.
- W82281364 hasRelatedWork W2416206042 @default.
- W82281364 hasRelatedWork W82281364 @default.
- W82281364 hasVolume "94" @default.
- W82281364 isParatext "false" @default.
- W82281364 isRetracted "false" @default.
- W82281364 magId "82281364" @default.
- W82281364 workType "article" @default.