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- W82293762 abstract "Water labeled with 0-15 (2.0 m half-life) can be used as a diffusible tracer to quantitate regional myocardial perfusion using PET and bolus injections (i.v.). This is the first report of the validation of a dynamic PET method wherein both the input and residue functions are discerned simultaneously without using arterial sampling. These studies underpin noninvasive myocardial perfusion studies with an inert diffusible tracer in which variability in physiological extraction with altered flows or ischemic conditions is not a concern as with Rb-82 and N-13 ammonia. A 7 s bolus venous injection of 0-15 (up to 20 mCi) was done simultaneously with left atrial infusion of microspheres in all 4 thoracotomized dogs. 0-15 was produced by the N-14(d,n)0-15 reaction at the 88-inch cyclotron. The input function is measured from the activity in a region of interest (ROI) over the left ventricular blood pool from sequential PET images (2.5 s intervals for 60 s; 10 s for 80 s; 20 s for 160 s totalling 5 min). The 0-15 water residue function is determined from the ROI over the myocardium as determined from a Rb-82 PET study. These two data sets are used to calculate rate constants in a two-compartment modelmore » which lumps the capillary and myocite membrane transport. This model is equivalent to the basic diffusible tracer equation for variable input. The rate constant k is related to flow via a partition coefficient of 0.91 and the tissue density of 1.05g/cc. In 9 studies with 4 dogs under normal and dipyridamole-induced high flow studies the authors found an excellent correlation (r=0.8) between PET water perfusion results and flow determined form the microsphere reference organ technique.« less" @default.
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- W82293762 date "1984-01-01" @default.
- W82293762 modified "2023-09-26" @default.
- W82293762 title "Myocardial perfusion by dynamic positron emission tomography (PET) using O-15-water" @default.
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