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- W823505933 abstract "目的研究3-氯-1, 2-丙二醇(3-MCPD)对人胚肾293(HEK293)细胞DNA损伤作用。 方法以HEK293细胞为靶细胞, 3-MCPD设5个剂量组:0, 1.25, 2.5, 5, 10 mmol/L, 应用单细胞凝胶电泳检测3-MCPD诱导的HEK293细胞DNA损伤; 将3-MCPD设4个剂量组:0, 2.5, 5, 10 mmol/L, 以2, 7-二氢二氯荧光素(DCFH)法测定HEK293细胞内活性氧(ROS)水平; 将3-MCPD设4个剂量组:0, 1.25, 2.5, 5 mmol/L, 通过免疫组化法测定8-羟基脱氧鸟苷(8-OHdG)在HEK293细胞内的表达水平。 结果与对照组比较, 1.25~10 mmol/L的染毒组细胞DNA链断裂, 细胞形成彗星样脱尾, 尾DNA%明显上升, 且呈剂量依赖关系(P < 0.05)。2.5~10 mmol/L的染毒组细胞内ROS水平表达升高, 在10 mmol/L时明显升高(P < 0.05)。1.25~5 mmol/L的染毒组细胞内8-OHdG表达水平上升, 在2.5和5 mmol/L时8-OHdG表达明显增强(P < 0.05)。 结论3-MCPD导致了HEK293细胞DNA损伤, 可能是通过细胞内ROS升高及8-OHdG形成增加所造成的氧化性DNA损伤作用。" @default.
- W823505933 created "2016-06-24" @default.
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- W823505933 date "2009-11-10" @default.
- W823505933 modified "2023-10-18" @default.
- W823505933 title "3-氯-1,2-丙二醇对人胚肾293细胞DNA损伤作用" @default.
- W823505933 doi "https://doi.org/10.11847/zgggws2009-25-11-43" @default.
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