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- W823823634 abstract "i Acknowledgements iii Declaration iv Content v List of Figures and Tables ix Abbreviations xii CHAPTER 1 GENERAL INTRODUCTION 1 1.1 Candida and Chronic Mucocutaneous Candidiasis 1 1.1.1 Infections caused by Candida 1 1.1.2 Primary immunodeficiency syndromes of CMC as a model for studying the Candida immunity 2 1.2 Protective immunity to Candida infections 2 1.2.1 Role of the innate immune system 2 1.2.2 Role of the adaptive immune system 5 1.3 Recent advances in understanding immune defects in PIDs with CMC 6 1.3.1 Hyper IgE syndrome – STAT3, DOCK8 and Tyk2 mutations 6 1.3.2 CMC – CARD9 and Dectin-1 mutations 7 1.3.3 CMC – IL-17F and IL-17RA mutations 8 1.3.4. CMC – IL-12RB1 mutations 8 1.3.5 APECED/APS1 – AIRE mutations 8 1.3.6 CMC – MST1/STK4 mutations 9 1.3.7 CMC – ACT1 mutations 9 1.3.8 CMC – Gain-of-function-STAT1 mutations 9 1.4 Signal transducer and activator of transcription signaling 11 1.4.1 STAT structure, function and regulation 11 1.4.2 STAT1 signaling and IFNs production 13 1.4.3 STAT3 signaling and IL-17 production 13" @default.
- W823823634 created "2016-06-24" @default.
- W823823634 creator A5075141324 @default.
- W823823634 date "2014-01-01" @default.
- W823823634 modified "2023-09-23" @default.
- W823823634 title "Gain-of-function STAT1 mutations impair STAT3 function and underlie susceptibility to Chronic Mucocutaneous Candidiasis" @default.
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