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- W824261707 abstract "The treatment of bacterial infection is becoming difficult due to the increasing resistance of most clinically relevant bacterial strains. New type of weapons to tackle this growing problem are, therefore, urgently needed. Drugs targeting virulence is an alternative approach to treat infections provoked by resistant bacteria. By weakening pathogenic bacteria, the “antivirulence strategy” intends to increase their sensitivity against the host innate immunity such as components of human complement but also to classical antibiotics. In this context, disrupting the Gram negative bacterial cell wall biosynthesis is particularly interesting to target, as well as the microbial adhesion process necessary for further colonization. We developed during this work, new glycoconjugates targeting the bacterial heptose biosynthetic pathway and new multivalent glycoconjugates targeting bacterial adhesion processes." @default.
- W824261707 created "2016-06-24" @default.
- W824261707 creator A5068956114 @default.
- W824261707 date "2011-01-01" @default.
- W824261707 modified "2023-09-27" @default.
- W824261707 title "Développement de glycoconjugués ciblant la virulence bactérienne." @default.
- W824261707 hasPublicationYear "2011" @default.
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