FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W82452007> ?p ?o ?g. }

• W82452007 endingPage "82" @default.
• W82452007 startingPage "59" @default.
• W82452007 abstract "Trimethyltin, when given by gavage to rats, has an LD50 of 12.6 mg/kg. Signs of poisoning include tremors, hyperexcitability, aggressive behavior, weight loss, and convulsions. After single (10 mg/kg) or repeated weekly doses (a maximum of four) of 4 mg/kg, rats, up to a survival time of 70 days, were perfusion-fixed for light microscopy. Trimethyltin was assayed in brain and blood in rats after similar treatments. Trimethyltin is cumulative and persistent and binds with high affinity to hemoglobin. Trimethyltin, unlike triethyltin, does not produce white matter edema in rats but does cause bilateral and symmetrical neuronal alterations involving the hippocampus (largely sparing the Sommer sector), pyriform cortex, amygdaloid nucleus, and neocortex. The earliest alteration was loss or dispersal of Nissl substance, then clumping of nuclear chromatin, followed by shrinkage and fragmentation of the nucleus within shrunken eosinophilic cytoplasm. These changes were associated with approximately 1.4 microgram trimethyltin/g wet weight in brain tissue 1 day after the second dose of 4 mg/kg or 2 days after a single dose of 10 mg/kg. Signs of poisoning gradually disappeared, and 4 rats surviving 70 days appeared normal, although their brains had severe damage with cell loss in the hippocampi and each pyriform cortex. Treatment of rats with trimethyltin, therefore, provides a chronic preparation with consistent lesions in the hippocampus of use in other behavioral and neuroanatomic studies. (Am J Pathol 97:59--82, 1979)." @default.
• W82452007 created "2016-06-24" @default.
• W82452007 creator A5002215473 @default.
• W82452007 creator A5029225511 @default.
• W82452007 creator A5035716657 @default.
• W82452007 creator A5067198228 @default.
• W82452007 date "1979-10-01" @default.
• W82452007 modified "2023-10-10" @default.
• W82452007 title "The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat." @default.
• W82452007 cites W125303941 @default.
• W82452007 cites W138422244 @default.
• W82452007 cites W1777721252 @default.
• W82452007 cites W1862598825 @default.
• W82452007 cites W1970669193 @default.
• W82452007 cites W1975157105 @default.
• W82452007 cites W1989223807 @default.
• W82452007 cites W1997087758 @default.
• W82452007 cites W2009072812 @default.
• W82452007 cites W2017983436 @default.
• W82452007 cites W2024332890 @default.
• W82452007 cites W2065326752 @default.
• W82452007 cites W2079173507 @default.
• W82452007 cites W2088762132 @default.
• W82452007 cites W2090747618 @default.
• W82452007 cites W2098093165 @default.
• W82452007 cites W2141899399 @default.
• W82452007 cites W2151725958 @default.
• W82452007 cites W2162684625 @default.
• W82452007 cites W2291112805 @default.
• W82452007 cites W2327108216 @default.
• W82452007 cites W2340295685 @default.
• W82452007 cites W2418751143 @default.
• W82452007 cites W3002740628 @default.
• W82452007 cites W3025312657 @default.
• W82452007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2042375" @default.
• W82452007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/495696" @default.
• W82452007 hasPublicationYear "1979" @default.
• W82452007 type Work @default.
• W82452007 sameAs 82452007 @default.
• W82452007 citedByCount "89" @default.
• W82452007 countsByYear W824520072012 @default.
• W82452007 countsByYear W824520072013 @default.
• W82452007 countsByYear W824520072014 @default.
• W82452007 countsByYear W824520072015 @default.
• W82452007 countsByYear W824520072017 @default.
• W82452007 countsByYear W824520072018 @default.
• W82452007 countsByYear W824520072022 @default.
• W82452007 crossrefType "journal-article" @default.
• W82452007 hasAuthorship W82452007A5002215473 @default.
• W82452007 hasAuthorship W82452007A5029225511 @default.
• W82452007 hasAuthorship W82452007A5035716657 @default.
• W82452007 hasAuthorship W82452007A5067198228 @default.
• W82452007 hasConcept C126322002 @default.
• W82452007 hasConcept C134018914 @default.
• W82452007 hasConcept C142724271 @default.
• W82452007 hasConcept C169760540 @default.
• W82452007 hasConcept C185592680 @default.
• W82452007 hasConcept C2777222312 @default.
• W82452007 hasConcept C2777348757 @default.
• W82452007 hasConcept C2780506209 @default.
• W82452007 hasConcept C2781161787 @default.
• W82452007 hasConcept C2781172350 @default.
• W82452007 hasConcept C37753355 @default.
• W82452007 hasConcept C71924100 @default.
• W82452007 hasConcept C74864618 @default.
• W82452007 hasConcept C86803240 @default.
• W82452007 hasConceptScore W82452007C126322002 @default.
• W82452007 hasConceptScore W82452007C134018914 @default.
• W82452007 hasConceptScore W82452007C142724271 @default.
• W82452007 hasConceptScore W82452007C169760540 @default.
• W82452007 hasConceptScore W82452007C185592680 @default.
• W82452007 hasConceptScore W82452007C2777222312 @default.
• W82452007 hasConceptScore W82452007C2777348757 @default.
• W82452007 hasConceptScore W82452007C2780506209 @default.
• W82452007 hasConceptScore W82452007C2781161787 @default.
• W82452007 hasConceptScore W82452007C2781172350 @default.
• W82452007 hasConceptScore W82452007C37753355 @default.
• W82452007 hasConceptScore W82452007C71924100 @default.
• W82452007 hasConceptScore W82452007C74864618 @default.
• W82452007 hasConceptScore W82452007C86803240 @default.
• W82452007 hasIssue "1" @default.
• W82452007 hasLocation W824520071 @default.
• W82452007 hasOpenAccess W82452007 @default.
• W82452007 hasPrimaryLocation W824520071 @default.
• W82452007 hasRelatedWork W1594448327 @default.
• W82452007 hasRelatedWork W1978555483 @default.
• W82452007 hasRelatedWork W2051942816 @default.
• W82452007 hasRelatedWork W2055300348 @default.
• W82452007 hasRelatedWork W2056316480 @default.
• W82452007 hasRelatedWork W2072536549 @default.
• W82452007 hasRelatedWork W2089452956 @default.
• W82452007 hasRelatedWork W2157415915 @default.
• W82452007 hasRelatedWork W2375813713 @default.
• W82452007 hasRelatedWork W2592279962 @default.
• W82452007 hasVolume "97" @default.
• W82452007 isParatext "false" @default.
• W82452007 isRetracted "false" @default.
• W82452007 magId "82452007" @default.

• next