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• W824565523 abstract "Puberty is a period of fast and interactive morphological, endocrine and behavioral changes. Currently, the exposure to environmental contaminants is considered one of the factors responsible for alterations in child development, resulting in pubertal precocity or delay. Many chemical compounds with domestic, industrial and agricultural use, known as endocrine disruptors, have shown hormonal activity. Some clinicians are beginning to evaluate some parameters related to the interference of these compounds in the development of children living in contaminated areas, but there are no studies correlating this delay on puberty with possible changes in the reproductive tract and fertility from sexual maturity. This study aimed to investigate whether a delay in puberty installation affects reproductive parameters in pubertal and adult male rats. Especially considering that the literature shows a wide range fixed for the beginning of puberty, the study also intended to analyze the parameters of puberty in normal rats, contributing to the establishment of an actual age for puberty in male Wistar rats. The onset of puberty was delayed through administration of a high doses of dibutyl phthalate (DBP) during the fetal period. We assessed morphofunctional parameters of the male reproductive tract, hormonal levels, sperm evaluations, and histopathologic and morphometric analysis of testis and epididymis. At puberty, the prostate weight of DBP-exposed animals was significantly reduced. The daily sperm production was reduced in the testis of the pubertal DBP-exposed rats, and this alteration remained in the adult rats. However, neither sperm morphology nor sperm motility was altered, as well as the capacity of fertilization assessed by AI. The histopathology of testis revealed a high number of tubules with abnormalities in DPB-exposed rats, in both ages. In the DBP-exposed animals malformations were found in the caput epididymis, as already reported in the literature after exposure to a high dose of DBP. In this model of delayed puberty in male rats, there was some alterations on reproductive tract, but they were not sufficient to alter the capacity of reproduction. In this pubertal age, the animals are capable of reproduction but do not have total sexual development, or reached their maximum capacity of reproduction. More studies are needed primarily for other species and using other models of alteration in the onset of puberty. “Ninguem e tao grande que nao possa aprender nem tao pequeno que nao possa ensinar” (Autor Desconhecido)" @default.
• W824565523 created "2016-06-24" @default.
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• W824565523 date "2011-02-23" @default.
• W824565523 modified "2023-09-28" @default.
• W824565523 title "Puberdade retardada no rato macho: correlações entre indicadores externos e internos e repercussões sobre a qualidade espermática e fertilidade" @default.
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