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- W8249318 abstract "Abstract Ghrelin, a circulating orexigenic hormone, exerts potent therapeutic effect in several models of inflammatory diseases, such as endotoxemic shock, ulcerative colitis and autoimmune encephalomyelitis. Suppression of production of pro-inflammatory cytokines from immune cells has been proposed as a mechanism of this effect of ghrelin. Here we report that ghrelin enhances lipopolysaccharide (LPS)-induced production of the anti-inflammatory cytokine IL-10 from human peripheral blood monocyte-derived macrophages. Interestingly, IL-10 production from LPS-activated monocytes was not affected by ghrelin. Further studies revealed that the ghrelin receptor, namely, growth hormone secretagogue receptor (GHS-R), is significantly upregulated during macrophage differentiation. Moreover, ghrelin enhanced expression of the transcription factor c-Maf essential for IL-10 gene expression in macrophages. Whether induction of c-Maf by ghrelin is responsible for the enhanced IL-10 production and the significance of IL-10 in overall anti-inflammatory action of ghrelin in vivo is currently under investigation." @default.
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- W8249318 date "2010-04-01" @default.
- W8249318 modified "2023-09-25" @default.
- W8249318 title "An orexigenic hormone ghrelin enhances LPS-induced IL-10 production in human peripheral blood-derived macrophages. (138.12)" @default.
- W8249318 doi "https://doi.org/10.4049/jimmunol.184.supp.138.12" @default.
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