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- W82573422 abstract "The most versatile neurophysiological paradigms for the study of cognitive function in animals are those that involve recording the activity of neurons in awake and behaving monkeys. Techniques for recording in behaving monkeys were originally developed by Herbert Jaspers and colleagues (Jasper et al., 1960) and elaborated by Edward Evarts (Evarts, 1966; Evarts, 1968) in the 1960s. Conventional recording methods, based on these early developments, employ single movable sharp electrodes to isolate single cells in regions of interest. Cells must be recorded serially over many weeks to accumulate enough data to characterize the population of cells under study. More recently, systems that permit several sharp electrodes—from approximately 2 to 16—to be independently positioned have improved the yield and allow the activity of several cells to be monitored simultaneously. Recordings of this kind, however, are generally restricted to a single cortical or subcortical site and can be maintained only for a short time.In this chapter, we will describe a range of contemporary and emerging methods for studying the activity of large numbers of neurons, in multiple cortical and subcortical locations, for periods extending from several weeks to several years. Techniques for conducting multielectrode recordings will be described with special emphasis on issues unique to conducting these experiments in behaving monkeys (readers interested in more detail will be directed to the more specialized chapters of this volume and other resources where appropriate). To demonstrate the value of these methods for addressing significant neuroscientific questions, an example of the use of multi-electrode recordings in behaving monkeys from our own work will be described." @default.
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- W82573422 date "2007-12-03" @default.
- W82573422 modified "2023-09-24" @default.
- W82573422 title "Multielectrode Recording in Behaving Monkeys" @default.
- W82573422 cites W2030018356 @default.
- W82573422 doi "https://doi.org/10.1201/9781420006414-14" @default.
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